130336-16-2Relevant articles and documents
Preparation method of trifluoroacetophenone derivative
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Paragraph 0037; 0040-0041; 0046; 0048; 0052; 0066-0075; 0079, (2021/10/05)
The invention relates to the field of organic synthesis, in particular to a preparation method of a trifluoroacetophenone derivative. Substituted aniline is used as a raw material, and preparation of the trifluoroacetophenone derivative is completed through three steps including diazotization reaction, coupling reaction and hydrolysis reaction. The preparation method has the advantages of simple process, high yield and less three wastes generated by the whole reaction, and is suitable for large-scale industrial production.
PROCESS FOR THE PREPARATION OF 3,5-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
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Page/Page column 8-9, (2021/12/08)
The present invention relates to an improved process for the preparation of 3,5-Dichloro-2,2,2-Trifluoroacetophenone of formula (I). The present invention further provides an improved process for the preparation of Fluralaner using 3,5-dichloro-2,2,2-trifluoroacetophenone of formula (I) obtained by a process described herein.
Preparation method of 3',5'-dichloro-2,2,2-trifluoroacetophenone
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Paragraph 0026-0053; 0060; 0063, (2020/12/31)
The invention relates to the technical field of chemical pharmacy, particularly to a preparation method of 3',5'-dichloro-2,2,2-trifluoroacetophenone. According to the invention, 3',5'-dichloro-2,2,2-trifluoroacetophenone is prepared from 3'-chloro-2,2,2-trifluoroacetophenone as a raw material through four steps of nitrification, reduction, chlorination and deamination, and the method has the advantages of low raw material cost, mild reaction conditions, simple reaction process, facilitation of the reduction of the production cost, and improvement of the economic effect.