13035-19-3

Basic information

• Product Name: 4-Aminopiperidine
• Synonyms: PIPERIDIN-4-YLAMINE;4-AMINOPIPERIDINE;4-PIPERIDINEAMINE;4-Amino;4-Aminopiperidine 97%;4-AMINOPIPERDINE 98+%;4-AMINO PIPERIDINE PIPERIDIN-4-YLAMINE;4-Piperidinamine
• CAS NO: 13035-19-3
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• EINECS: 1533716-785-6
• Product Categories: Piperidines, Piperidones, Piperazines;Piperidine;Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 13035-19-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 25 °C
• Boiling Point: 65°C 18mm
• Flash Point: >230 °F
• Appearance: Off-white to yellow/Powder
• Density: 0.945 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.57mmHg at 25°C
• Refractive Index: n20/D 1.4910(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.37±0.20(Predicted)
• Sensitive: Hygroscopic
• BRN: 1105
• CAS DataBase Reference: 4-Aminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminopiperidine(13035-19-3)
• EPA Substance Registry System: 4-Aminopiperidine(13035-19-3)

Safety Data

• Hazard Codes: C,Xi
• Statements: 10-34
• Safety Statements: 16-23-26-36/37/39-45-6
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 13035-19-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 13035-19-3 differently. You can refer to the following data:
1. Reactant for synthesis of 4-Aminopiperidine: Cdk5/p25 kinase inhibitors Antimalarials Selective cyclin-dependent kinase 4/6 inhibitors IKKβ inhibitors Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation Human and murine soluble epoxide hydrolase inhibitors
2. Reactant for synthesis of:Cdk5/p25 kinase inhibitorsAntimalarialsSelective cyclin-dependent kinase 4/6 inhibitorsIKKβ inhibitorsOrally bioavailable P2Y12 antagonists for inhibition of platelet aggregationHuman and murine soluble epoxide hydrolase inhibitors

InChI:InChI=1/C5H12N2/c6-5-1-3-7-4-2-5/h5,7H,1-4,6H2

Upstream product

• 7732-18-5 water 
• 178667-08-8 [4]piperidyl-dicarbothioamidoic acid 
• 64-17-5 ethanol 
• 7553-56-2 iodine 
• 504-24-5 4-aminopyridine 
• 7664-93-9 sulfuric acid 
• 626-61-9 4-Chloropyridine 
• 14906-56-0 4-Acetamino-pyridin-1-oxid 
• 1124-33-0 4-nitraminopyridine N-oxide 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 100368-03-4 piperidine-4-carboxylic acid hydrazide; dihydrochloride 
• 856846-18-9 N-(1-acetyl-[4]piperidyl)-acetamide 

Downstream Products

• 527680-15-5 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-1,6-naphthyridin-2(1H)-one 
• 444661-91-0 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one 
• 63921-23-3 1-phenylpiperidin-4-ylamine 
• 23056-29-3 phenyl-piperidin-4-yl-amine 
• 260360-16-5 4-N-(2-methoxyphenyl)aminopiperidine 
• 1029643-92-2 N-phenylmethylidenepiperidinyl-4-amine 
• 501673-75-2 1-tert-butoxycarbonyl-4-[(2-methoxyphenyl)amino]piperidine 
• 933056-02-1 1-tert-butoxycarbonyl-4-[(2-ethylphenyl)amino]piperidine 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 

Related news

4-Aminopiperidine (cas 13035-19-3) derivatives as a new class of potent cognition enhancing drugs09/09/2019

Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a ne...detailed

Design and synthesis of novel small molecule CCR2 antagonists: Evaluation of 4-Aminopiperidine (cas 13035-19-3) derivatives09/08/2019

A novel N-(2-oxo-2-(piperidin-4-ylamino)ethyl)-3-(trifluoromethyl)benzamide series of human CCR2 chemokine receptor antagonists was identified. With a pharmacophore model based on known CCR2 antagonists a new core scaffold was designed, analogues of it synthesized and structure–affinity relatio...detailed

Evaluation of a 4-Aminopiperidine (cas 13035-19-3) replacement in several series of CCR5 antagonists09/04/2019

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.detailed

Relevant articles and documents

USE OF INTERMEDIATES ((R ) -2,2, 4-TRIMETHYL-L, 3-DIOXOLANE-4-YL) METHANOL (A), 3-F LUORO-4-NITRO-PHENOL (B) AND 1- (4-CHLORO- BENZYL) -PIPERIDIN-4-YLAMINE (C)

The present invention relates to novel processes for the preparation of intermediate compounds which can be used to prepare therapeutic agents. The present invention also relates to novel intermediate compounds which can be used to prepare therapeutic agents. More specifically, the invention relates to the use of intermediates ((R) -2,2,4-trimethyl-l, 3- dioxolane-4 -yl) methanol (A), 3-f luoro-4-nitro-phenol (B) and 1- (4-chloro-benZyl) -piperidin-4-ylamine (C).

Indazole derivatives having monocyclic amine

An indazole compound having the formula (I): wherein: R1 is hydrogen, C1 -C6 alkyl, C3 -C6 alkenyl or C3 -C6 cycloalkyl; Q is carbonyl, thiocarbonyl or methylene; and R2 is a group of the formula (II) or (IV); STR1 wherein R1 is C1 -C6 alkyl, C3 -C6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT4 receptor agonist activity.