130350-97-9

Basic information

• Product Name: Silane, (2-bromophenyl)chlorodimethyl-
• CAS NO: 130350-97-9
• Molecular Formula: C8H10BrClSi
• Molecular Weight: 249.61
• Mol File: 130350-97-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Silane, (2-bromophenyl)chlorodimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (2-bromophenyl)chlorodimethyl-(130350-97-9)
• EPA Substance Registry System: Silane, (2-bromophenyl)chlorodimethyl-(130350-97-9)

Safety Data

• Hazardous Substances Data: 130350-97-9(Hazardous Substances Data)

Upstream product

• 75-78-5 dimethylsilicon dichloride 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 451486-03-6 C₅₇H₉₂BrNO₁₂Si₂ 
• 1160757-56-1 C₁₄H₁₅BrSi 
• 1411715-43-9 (2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethyl(4-(trifluoromethyl)phenyl)silane 
• 1411715-41-7 (4-chlorophenyl)(2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethylsilane 
• 1411715-39-3 (2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)(4-fluorophenyl)dimethylsilane 
• 1411715-37-1 (2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethyl(p-tolyl)silane 
• 1411715-35-9 (4-butoxyphenyl)(2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethylsilane 
• 1411715-33-7 (4-butoxyphenyl)(2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethylsilane 
• 1411715-31-5 4-((2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethylsilyl)-N,N-dimethylaniline 
• 1309154-13-9 (2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethyl(phenyl)silane 
• 1411715-26-8 benzyl(2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)dimethylsilane 
• 1160757-47-0 1-methyl-1-phenyl-2,3-dipropyl-1H-benzo[b]silole 
• 1016642-73-1 1,1-dimethyl-2,3-diphenyl-1H-benzo[b]silole 
• 1411714-96-9 1-methyl-2,3-diphenyl-1-(4-(trifluoromethyl)phenyl)-1H-benzo[b]silole 

Relevant articles and documents

Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles

Silicon-containing compounds have been largely ignored in drug design and development, despite their potential to improve not only the potency but also the physicochemical and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties of drug-like candidates because of the unique characteristics of silicon. This deficiency is in large part attributable to a lack of general methods for synthesizing diverse organosilicon structures. Accordingly, a new building block strategy has been developed that diverges from traditional approaches to incorporation of silicon into drug candidates. Flexible, multi-gram-scale syntheses of silicon-containing tetrahydroquinoline and tetrahydroisoquinoline building blocks are described, along with methods by which diversely functionalized silicon-containing nitrogen heterocycles can be rapidly built using common reactions optimized to accommodate the properties of silicon. Furthermore, to better clarify the liabilities and advantages of silicon incorporation, select compounds and their carbon analogues were challenged in ADMET-focused biological studies.