130641-22-4

Basic information

• Product Name: (R)-5-((1R,2R)-1-Carbamoyl-2-hydroxy-propyl)-3-(2-formimidoylamino-ethylsulfanyl)-1-formyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
• Synonyms: (R)-5-((1R,2R)-1-Carbamoyl-2-hydroxy-propyl)-3-(2-formimidoylamino-ethylsulfanyl)-1-formyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
• CAS NO: 130641-22-4
• Molecular Weight: 344.392
• Mol File: 130641-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-5-((1R,2R)-1-Carbamoyl-2-hydroxy-propyl)-3-(2-formimidoylamino-ethylsulfanyl)-1-formyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-((1R,2R)-1-Carbamoyl-2-hydroxy-propyl)-3-(2-formimidoylamino-ethylsulfanyl)-1-formyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid(130641-22-4)
• EPA Substance Registry System: (R)-5-((1R,2R)-1-Carbamoyl-2-hydroxy-propyl)-3-(2-formimidoylamino-ethylsulfanyl)-1-formyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid(130641-22-4)

Safety Data

• Hazardous Substances Data: 130641-22-4(Hazardous Substances Data)

Upstream product

• 3473-63-0 formamidine acetic acid 
• 118334-32-0 imipenem 

Relevant articles and documents

Stability and kinetics of degradation of imipenem in aqueous solution

In weakly acidic solution, the broad-spectrum antibiotic imipenem undergoes complex oligomerization initiated by intermolecular carboxyl group attack on the β-lactam group. In weakly alkaline solution, intermolecular reaction between the β-lactam and formimidoyl groups occurs instead. Both β-lactam and formimidoyl groups also hydrolyze at pH-dependent rates. Complex decomposition schemes were determined in kinetic studies at pH 4.0 and 9.0-9.5 using HPLC and mathematical models. The rates of the several initial reactions, calculated as functions of pH and imipenem concentration by fitting the models to kinetic data, fully account for imipenem decomposition rates throughout the neutral pH range.