130990-25-9Relevant articles and documents
COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING
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Paragraph 0625; 0632-0634, (2021/08/06)
Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.
Hydrogenation of citric acid
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, (2008/06/13)
A process for the preparation of propane-1,2,3-tricarboxylic acid, tetrahydrofurfurylacetic acid and the C1 - to C20 -alkyl or C7 - to C12 -aralkyl esters thereof, propane-1,2,3-trimethanol, 3-methyltetrahydrofuran, 3-(2'-hydroxyethyl)tetrahydrofuran, 4-hydroxymethyltetrahydropyran, 2-methyl-γ-butyrolactone and/or 3-methyl-γ-butyrolactone, comprises reacting citric acid or the C1 - to C20 -alkyl or C7 - to C12 -aralkyl esters thereof on hydrogenation catalysts in non-aqueous solvents at from 50° to 400° C. and at from 1 to 400 bar.