13161-88-1Relevant articles and documents
Synthesis and antiparasitic activity of new 1-nitro, 1-amino and 1-acetamido 9-acridinones
Ngadi,Bsiri,Mahamoud,Galy,Galy,Soyfer,Barbe,Placidi,Rodriguez-Santiago,Mesa-Valle,Lombardo,Mascaro,Osuna
, p. 480 - 483 (2007/10/02)
The synthesis of 1-amino-10-alkyl-9-acridinones 4 and 5 and of homologous 9-thio-acridinones 7 and 8 are described. Similarly, the synthesis of 1-nitro-4-(2'-aminoethylamino)-9-acridinones 13 and 15, is described. Compound 4 was used as starting material for the preparation of 10-alkyl-9-acridinone dimers 6, bridged with an α,ω-diamido chain. Compound 15 was selected for biological investigations on pathogenic parasite strains, and a promising antiamoebic activity could be shown.
Synthesis and Cyclization Reactions of 4--9-(3-Dimethylaminopropylamino)-1-Nitroacridines: Approaches to the Synthesis of 'Nitracrine Mustard'
Chambers, David,Denny, William A.
, p. 1055 - 1060 (2007/10/02)
Compounds which can be selectively activated to cytotoxic species in hypoxic mammalian cells have potential for the treatment of solid tumours, which uniquely contain cells in such an environment.One approach to such drugs is exemplified by the title comp