13162-26-0

Basic information

• Product Name: 2,4-Dichloro-6-methyl-5-nitropyrimidine
• Synonyms: 2,4-DICHLORO-6-METHYL-5-NITROPYRIMIDINE;2,4-DICHLORO-5-NITRO-6-METHYLPYRIMIDINE;2,4-Dichloro-6-Methyl-5-Nitro;Pyrimidine, 2,4-dichloro-6-methyl-5-nitro-;2,6-DICHLORO-4-METHYL-5-NITROPYRIMIDINE;2,4-Dichloro-6-methyl-5-nitropyrimidine ,98%;2,4-dichloro-6-methyl-5-nitropyrimidin;4-Dichloro-6-Methyl-5-nitro-pyriMidine
• CAS NO: 13162-26-0
• Molecular Formula: C₅H₃Cl₂N₃O₂
• Molecular Weight: 208
• EINECS: 1533716-785-6
• Product Categories: Pyrimidine Series;APIs & Intermediate;Pyrimidine;Pyridines, Pyrimidines, Purines and Pteredines;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Nucleotides;Heterocycle-Pyrimidine series
• Mol File: 13162-26-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 52-54°C
• Boiling Point: 311.8 °C at 760 mmHg
• Flash Point: 142.4 °C
• Appearance: yellow crystalline solid
• Density: 1.626 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -5.30±0.39(Predicted)
• Stability: Moisture Sensitive
• CAS DataBase Reference: 2,4-Dichloro-6-methyl-5-nitropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-6-methyl-5-nitropyrimidine(13162-26-0)
• EPA Substance Registry System: 2,4-Dichloro-6-methyl-5-nitropyrimidine(13162-26-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41-36/37/38
• Safety Statements: 26-39-36/37/39
• Hazardous Substances Data: 13162-26-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Crystalline Solid

Uses

A synthetic intermediate

InChI:InChI=1/C5H3Cl2N3O2/c1-2-3(10(11)12)4(6)9-5(7)8-2/h1H3

Upstream product

• 16632-21-6 5-nitro-6-methyluracil 
• 10025-87-3 trichlorophosphate 
• 626-48-2 6-Methyluracil 
• 16632-21-6 6-methyl-5-nitropyrimidine-2,4-diol 
• 121-69-7 N,N-dimethyl-aniline 
• 626-48-2 2,4-dihydroxy-6-methylpyrimidine 

Downstream Products

• 874495-11-1 (2-methoxy-6-methyl-5-nitro-pyrimidin-4-yl)-[2]pyridyl-amine 
• 2829-59-6 6-methyl-2,4-diamino-5-nitropyrimidine 
• 5453-06-5 4-Amino-5-nitro-6-methyl-2-chloropyrimidine 
• 917596-58-8 2-ethoxy-6-methyl-5-nitro-pyrimidin-4-ol 
• 724762-15-6 2-benzyl-2-[2,6-bis(dibenzylamino)-5-nitropyrimidin-4-yl]-3-phenylpropionitrile 

Relevant articles and documents

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NITRATION

The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromatic ring comprises at least one heteroatom selected from the group consisting of oxygen, sulfur, phosphor, selenium and nitrogen, with a compound of formula (I) wherein Y is selected from the group consisting of hydrogen and nitro.

SAR studies on a novel series of human cytomegalovirus primase inhibitors

A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC50 values of 150 nM in both