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Cas Database

1316754-43-4

1316754-43-4

Identification

  • Product Name:C24H29N5O

  • CAS Number: 1316754-43-4

  • EINECS:

  • Molecular Weight:403.527

  • Molecular Formula: C24H29N5O

  • HS Code:

  • Mol File:1316754-43-4.mol

Synonyms:

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Relevant articles and documentsAll total 1 Articles be found

Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4- phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives

Nagarapu, Lingaiah,Mateti, Jhansi,Gaikwad, Hanmant K.,Bantu, Rajashaker,Sheeba Rani,Prameela Subhashini

, p. 4138 - 4140 (2011/08/06)

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5- carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.

Process route upstream and downstream products

Process route

3-(4-phenylpiperazin-1-yl)propan-1-amine
20529-19-5

3-(4-phenylpiperazin-1-yl)propan-1-amine

C<sub>24</sub>H<sub>29</sub>N<sub>5</sub>O
1316754-43-4

C24H29N5O

Conditions
Conditions Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate
1316754-28-5,942040-14-4

ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate

C<sub>24</sub>H<sub>29</sub>N<sub>5</sub>O
1316754-43-4

C24H29N5O

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: lithium hydroxide / tetrahydrofuran / 12 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;
2-[3-(4-penylpiperazin-1-yl)propyl]-1H-isoindole-1,3(2H)-dione
25557-30-6

2-[3-(4-penylpiperazin-1-yl)propyl]-1H-isoindole-1,3(2H)-dione

C<sub>24</sub>H<sub>29</sub>N<sub>5</sub>O
1316754-43-4

C24H29N5O

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: hydrazine / methanol / 24 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; In methanol; dichloromethane;
4-phenyl-1-piperazine
92-54-6

4-phenyl-1-piperazine

C<sub>24</sub>H<sub>29</sub>N<sub>5</sub>O
1316754-43-4

C24H29N5O

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: hydrazine / methanol / 24 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; In methanol; dichloromethane; N,N-dimethyl-formamide;
ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

C<sub>24</sub>H<sub>29</sub>N<sub>5</sub>O
1316754-43-4

C24H29N5O

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: acetic acid; hydrazine / 12 h / 20 °C
2: lithium hydroxide / tetrahydrofuran / 12 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; hydrazine; In tetrahydrofuran; dichloromethane;
3-Methylacetophenone
585-74-0

3-Methylacetophenone

C<sub>24</sub>H<sub>29</sub>N<sub>5</sub>O
1316754-43-4

C24H29N5O

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: sodium methylate / diethyl ether / 15 h / 20 °C
2: acetic acid; hydrazine / 12 h / 20 °C
3: lithium hydroxide / tetrahydrofuran / 12 h / 20 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With sodium methylate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; hydrazine; In tetrahydrofuran; diethyl ether; dichloromethane;

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