131748-14-6

Basic information

• Product Name: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
• Synonyms: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE;4-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE;4-Chloro-2-(TrifluoroMeth;4-Chloro-alpha,alpha,alpha-trifluoro-2-picoline;2-Trifluoromethyl-4-Chloropyridine(WX636118)
• CAS NO: 131748-14-6
• Molecular Formula: C₆H₃ClF₃N
• Molecular Weight: 181.54
• EINECS: 1312995-182-4
• Product Categories: Fluorine series;alkyl chloride
• Mol File: 131748-14-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 137.403 °C at 760 mmHg
• Flash Point: 36.9 °C
• Appearance: Colorless/Liquid
• Density: 1.417
• Vapor Pressure: 8.756mmHg at 25°C
• Refractive Index: 1.447
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.29±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(131748-14-6)
• EPA Substance Registry System: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(131748-14-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 131748-14-6(Hazardous Substances Data)

Usage

Uses

Chloro(trifluoromethyl)pyridines derivatives are used as model substrates for regioexhaustive functionalization.

InChI:InChI=1/C6H3ClF3N/c7-4-1-2-11-5(3-4)6(8,9)10/h1-3H

Upstream product

• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 

Downstream Products

• 1449243-22-4 C₁₉H₂₀F₄N₂O₃ 
• 1448541-18-1 N-(2-methylpyrimidin-4-yl)-2-[3-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetamide 
• 1313399-64-2 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine 
• 1313399-63-1 N-tert-butyloxycarbonyl-protected 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine 
• 1448594-73-7 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride 
• 1448545-14-9 6-(1-fluoroethyl)-N-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethyl]-2-methyl-pyrimidin-4-amine 
• 1605945-22-9 4-[[2-(4-fluorophenyl)-5-methyl-2H-1,2,3-triazol-4-yl]oxy]-2-(trifluoromethyl)pyridine 
• 588702-68-5 2-trifluoromethyl-isonicotinic acid methyl ester 
• 1214351-44-6 2-trifluoromethyl-isonicotinic acid ethyl ester 
• 131747-41-6 2-(trifluoromethyl)-4-pyridinecarboxylic acid 
• 916210-02-1 2-(trifluoromethyl)pyridine-4-carbonitrile 
• 1620-79-7 4-methyl-2-(trifluoromethyl)pyridine 
• 916210-33-8 tert-butyl {[2-(trifluoromethyl)pyridin-4-yl]methyl}carbamate 
• 147149-98-2 2-(trifluoromethyl)pyridin-4-amine 

Relevant articles and documents

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS

The invention relates to a novel process for the preparation of 2- trifluoromethyl isonicotinic acid and esters of the formula I which involves a palladium catalysed carbonylation or cyanation step wherein R1 is hydrogen or Q1-6-alkyl. The 2-trifluoromethyl isonicotinic acid and esters of the formula I are versatile intermediates for the preparation of active pharmaceutical and agrochemical agents such as for instance TAAR 1 agonists of the formula III.