1317668-12-4

Basic information

• Product Name: 4-{[benzyl(methyl)amino]methyl}-N-[2-(6-methoxy-1H-indol-3-yl)ethyl]benzamide
• Synonyms: 4-{[benzyl(methyl)amino]methyl}-N-[2-(6-methoxy-1H-indol-3-yl)ethyl]benzamide
• CAS NO: 1317668-12-4
• Molecular Weight: 427.546
• Mol File: 1317668-12-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{[benzyl(methyl)amino]methyl}-N-[2-(6-methoxy-1H-indol-3-yl)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[benzyl(methyl)amino]methyl}-N-[2-(6-methoxy-1H-indol-3-yl)ethyl]benzamide(1317668-12-4)
• EPA Substance Registry System: 4-{[benzyl(methyl)amino]methyl}-N-[2-(6-methoxy-1H-indol-3-yl)ethyl]benzamide(1317668-12-4)

Safety Data

• Hazardous Substances Data: 1317668-12-4(Hazardous Substances Data)

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 191869-65-5 4-((methyl(phenylmethyl)amino)methyl)benzonitrile 
• 1605289-52-8 N-benzyl-1-(4-carboxyphenyl)-N-methylmethanaminium chloride 
• 3610-36-4 2-(6-methoxy-1H-indol-3-yl)ethanamine 
• 17201-43-3 4-cyanobenzyl bromide 

Relevant articles and documents

New melatonin- N, N -dibenzyl(N -methyl)amine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for alzheimers disease

Here, we describe a new family of melatonin-N,N-dibenzyl(N-methyl)amine hybrids that show a balanced multifunctional profile covering neurogenic, antioxidant, cholinergic, and neuroprotective properties at low-micromolar concentrations. They promote maturation of neural stem cells into a neuronal phenotype and thus they could contribute to CNS repair. They also protect neural cells against mitochondrial oxidative stress, show antioxidant properties, and inhibit human acetylcholinesterase (AChE). Moreover, they displace propidium from the peripheral anionic site of AChE, preventing the β-amyloid aggregation promoted by AChE. In addition, they show low cell toxicity and can penetrate into the CNS. This multifunctional profile highlights these melatonin-N,N-dibenzyl(N-methyl)amine hybrids as useful prototypes in the research of innovative drugs for Alzheimers disease.