13177-52-1Relevant articles and documents
Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility
Williams, Hywel D.,Sahbaz, Yasemin,Ford, Leigh,Nguyen, Tri-Hung,Scammells, Peter J.,Porter, Christopher J. H.
supporting information, p. 1688 - 1690 (2014/02/14)
Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
Further investigation of the biodegradability of imidazolium ionic liquids
Harjani, Jitendra R.,Farrell, Jeff,Garcia, M. Teresa,Singer, Robert D.,Scammells, Peter J.
experimental part, p. 821 - 829 (2010/04/23)
In continuation of our earlier investigations, this report presents a rationale behind the design of a series of imidazolium based ionic liquids and their biodegradation using the CO2 headspace test (ISO 14593 method, OECD 310). The effect on biodegradability of these salts through variation of the N-substituted side chains of imidazolium ions was examined further through incorporation of various functional groups and increased alkyl chain lengths. A series of anions containing moieties known to be biodegradable were also incorporated into a number of imidazolium based salts and examined in a similar fashion.
