131987-69-4

Basic information

• Product Name: Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-
• CAS NO: 131987-69-4
• Molecular Formula: C13H17N3OS
• Molecular Weight: 263.363
• Mol File: 131987-69-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-(131987-69-4)
• EPA Substance Registry System: Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-(131987-69-4)

Safety Data

• Hazardous Substances Data: 131987-69-4(Hazardous Substances Data)

Upstream product

• 19779-06-7 sodium hexanolate 
• 131986-28-2 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine 

Downstream Products

• 131986-45-3 xanomeline 
• 141064-23-5 Xanomeline oxalate 
• 131988-19-7 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide 

Relevant articles and documents

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation

Series of analogs to the functional m1 selective agonist, xanomeline (hexyloxy-TZTP), were evaluated for their in vitro ml efficacy in cell lines transfected with the human m1 receptor. Systematic variation of the side chain and the azacyclic ring led to the discovery of potent muscarinic agonists with robust m1 efficacy, all having the phenylpropargyloxy/thio as the side chain. The most selective compound was the phenylpropargylthio- [3.2.1] endo analog 28, which is a potent and efficacious m1 agonist with no m2 activity.