132896-18-5

Basic information

• Product Name: 5-TRIFLUOROMETHYLBENZO[B]THIOPHENE
• Synonyms: 5-TRIFLUOROMETHYLBENZO[B]THIOPHENE;5-(trifluoromethyl)benzothiophene
• CAS NO: 132896-18-5
• Molecular Formula: C₉H₅F₃S
• Molecular Weight: 202.2
• Mol File: 132896-18-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 50 °C
• Boiling Point: 232.297 °C at 760 mmHg
• Flash Point: 94.29 °C
• Appearance: /
• Density: 1.38 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-TRIFLUOROMETHYLBENZO[B]THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TRIFLUOROMETHYLBENZO[B]THIOPHENE(132896-18-5)
• EPA Substance Registry System: 5-TRIFLUOROMETHYLBENZO[B]THIOPHENE(132896-18-5)

Safety Data

• Hazardous Substances Data: 132896-18-5(Hazardous Substances Data)

Usage

General Description

5-Trifluoromethylbenzo[b]thiophene is a chemical compound belonging to the category of organofluorines, more precisely a group of benzo[b]thiophenes. Benzo[b]thiophenes are hybrid structures that include a fused benzoic acid and thiophene group. The addition of trifluoromethyl provides the molecule with unique properties, such as increased reactivity, and chemical stability under various ambient conditions. This chemical is often used in pharmaceutical and material science research due to its potential utility in synthesizing complex molecules. Additionally, it's sometimes utilized in the preparation of various organic compounds. However, information about its toxicity, safety measures or environmental impacts might not be widely available, urging caution in its handling and usage.

Upstream product

• 19301-35-0 benzo[b]thiophen-5-ol 
• 98-56-6 4-chlorobenzotrifluoride 
• 74-86-2 acetylene 
• 110-81-6 Diethyl disulfide 
• 244126-64-5 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid 

Downstream Products

• 1184850-41-6 4,4,5,5-tetramethyl-2-(5-trifluoromethyl-benzo[b]thiophen-2-yl)-[1,3,2]dioxaborolane 

Relevant articles and documents

Nickel-Mediated Trifluoromethylation of Phenol Derivatives by Aryl C?O Bond Activation

The increasing pharmaceutical importance of trifluoromethylarenes has stimulated the development of more efficient trifluoromethylation reactions. Tremendous efforts have focused on copper- and palladium-mediated/catalyzed trifluoromethylation of aryl halides. In contrast, no general method exists for the conversion of widely available inert electrophiles, such as phenol derivatives, into the corresponding trifluoromethylated arenes. Reported herein is a practical nickel-mediated trifluoromethylation of phenol derivatives with readily available trimethyl(trifluoromethyl)silane (TMSCF3). The strategy relies on PMe3-promoted oxidative addition and transmetalation, and CCl3CN-induced reductive elimination. The broad utility of this transformation has been demonstrated through the direct incorporation of trifluoromethyl into aromatic and heteroaromatic systems, including biorelevant compounds.

ARYL-HYDROXYETHYLAMINO-PYRIMIDINES AND TRIAZINES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

HIGH-TEMPERATURE ORGANIC SYNTHESIS. XVII. REACTION OF CHLOROBENZENE AND ITS DERIVATIVES WITH DIALKYL DISULFIDES

The products from the reaction of chlorobenzene with dialkyl disulfides in the gas phase at 550-650 deg C are benzene, thiophenol, diphenyl sulfide, and also toluene, thiophene, and benzothiophene.Diethyl disulfide is most reactive.Its copyrolysis with chlorobenzene is distinguished by high selectivity for the formation of thiophenol, the yield of which amounts to 60percent.In the reaction of substituted chlorobenzenes and also 2-chlorothiophene and 1-chloronaphthalene with diethyl disulfide the corresponding thiols were obtained with high yields.Two paths for the formation of thiophene during the pyrolysis of dialkyl disulfide were established, i.e., from vinyl hydrosulfide and S-butyl radical.The last reaction is realized at a high rate.