1332327-19-1

Basic information

• Product Name: C₁₄H₁₇N₅O₂
• CAS NO: 1332327-19-1
• Molecular Weight: 287.321
• Mol File: 1332327-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₇N₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₇N₅O₂(1332327-19-1)
• EPA Substance Registry System: C₁₄H₁₇N₅O₂(1332327-19-1)

Safety Data

• Hazardous Substances Data: 1332327-19-1(Hazardous Substances Data)

Upstream product

• 6601-22-5 2,6-Dichloro-4-morpholino-1,3,5-triazine 

Downstream Products

• 1197162-85-8 N-[2-(dimethylamino)ethyl]-4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)-N-methylbenzamide 
• 1197162-87-0 4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)-N-methyl-N-[2-(methylamino)ethyl]benzamide 
• 1197162-89-2 1-{4-[(3,3-dimethylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea 
• 1197162-90-5 4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)-N-(2-piperidin-1-ylethyl)benzamide 
• 1197162-88-1 1-[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea 
• 1197162-86-9 N-[2-(dimethylamino)ethyl]-4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide 

Relevant articles and documents

Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors

We recently described several highly potent, triazine (1) and triazolopyrimidine (2) scaffold-based, dual PI3K/mTOR-inhibitors (e.g., 1, PKI-587) that were efficacious in both in vitro and in vivo models. In order to further optimize these compounds we devised a novel series, the 2-oxatriazines, which also exhibited excellent potency and good metabolic stability. Some 2-oxatriazines showed promising in vivo biomarker suppression and induced apoptosis in the MDA-MB-361 breast cancer xenograft model.