1332391-11-3Relevant articles and documents
Method for preparing
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, (2021/08/25)
The invention relates to a method for preparing an intermediate and an epalutamide, wherein the compound is represented by the formula (5). The preparation method of the compound represented by the formula (5) comprises the following steps: preparing compound represented by formula (3) by using the compound as an intermediate. Compound of formula (4) and Thithio reagent is reacted to form the compound represented by formula (5). The thio reagent is a phenyl thioformate. A combination of one or more N-thiocarbonyldiimidazole, 1,1 -thiocarbonyl DI-2 (1H) - pyridine. The inventors have found that 4 - (1 - carboxamide - cyclobutylamino) -2 - fluoro - N - methyl - benzamide, 5 - amino -2 - cyano -3 - trifluoromethyl pyridine and sodium thiochloroformate can be obtained in a higher yield than the prior art by one-step reaction under appropriate conditions. Based on this finding, the present invention was obtained and presented by further study.