13327-12-3

Basic information

• Product Name: 1-Piperidineacetamide, N-(2,6-dimethylphenyl)-
• CAS NO: 13327-12-3
• Molecular Formula: C15H22N2O
• Molecular Weight: 246.352
• Mol File: 13327-12-3.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperidineacetamide, N-(2,6-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidineacetamide, N-(2,6-dimethylphenyl)-(13327-12-3)
• EPA Substance Registry System: 1-Piperidineacetamide, N-(2,6-dimethylphenyl)-(13327-12-3)

Safety Data

• Hazardous Substances Data: 13327-12-3(Hazardous Substances Data)

Usage

Derived from

piperidine

Acetamide group

present

2,6-dimethylphenyl group

attached to the piperidine ring

Usage

production of pharmaceuticals, agrochemicals, and organic synthesis; potential applications in research and development

Biological and chemical properties

may vary depending on the application and context

Upstream product

• 87-62-7 2,6-dimethylaniline 
• 626-67-5 N-methylcyclohexylamine 
• 40397-98-6 2,5-dimethylphenyl isocyanate 
• 110-89-4 piperidine 
• 1131-01-7 2-chloro-N-(2,6-dimethylphenyl)acetamide 

Downstream Products

• 110334-85-5 1-[(2,6-dimethyl-phenylcarbamoyl)-methyl]-1-methyl-piperidinium; iodide 
• 119569-81-2 2,6-dimethyl-N-[2-(piperidin-1-yl)ethyl]aniline 

Relevant articles and documents

Versatile Bulky N,N′,N′-Substituted 1,2-Ethanediamine Ligands and Their Lithium, Aluminium, and Gallium Derivatives

Sterically demanding N,N′,N′-substituted 1,2-ethanediamine ligands have been prepared from commercially available starting materials by applying a facile one-step procedure. These ligands offer advantages compared to known systems: a suppressed delocalization due to the saturated backbone inhibits a noninnocent behaviour and the low symmetry of the related metal complexes makes them potential candidates for asymmetric catalysis. The ligands are readily transformed into the corresponding lithium derivatives 4, which in turn act as starting materials to access the corresponding aluminium and gallium dichlorides 5 and 6, respectively. In addition, deprotonation by Al(CH3)3gives rise to the related dimethylalane 7. All main-group element compounds have been studied by means of single X-ray crystallography and spectroscopic methods.

Radical fixation of functionalized carbon resources: α-sp 3C - H carbamoylation of tertiary amines with aryl isocyanates

A new carbamoylation of tertiary amines is reported. This rare C - H transformation features the direct generation of α-aminoalkyl radicals from tertiary amines, followed by the addition of the resultant nucleophilic radicals to isocyanates, enabling unique access to N,N-dialkylated amino acid derivatives. The authors put forward a mechanistic proposal that is based on the isolation of borinamides produced by capturing nitrogen radical intermediates with Et3B. The present transformation provides a novel one-step process for producing mepivacaine, a clinically important local anesthetic, from readily available materials.

SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION

Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 μ, produced by nebulization or dry powder inhaler.