1335107-64-6Relevant articles and documents
Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors
Huang, Wei-Jan,Chen, Ching-Chow,Chao, Shi-Wei,Yu, Chia-Chun,Yang, Chen-Yui,Guh, Jih-Hwa,Lin, Yun-Chieh,Kuo, Chiao-I.,Yang, Ping,Chang, Chung-I.
, p. 4042 - 4049 (2011/11/12)
Our previous studies have demonstrated that osthole, a Chinese herbal compound, could be incorporated into the hydroxycinnamide scaffold of LBH-589, a potent HDAC inhibitor, as an effective hydrophobic cap; the resulting compounds showed significant poten