13365-64-5

Basic information

• Product Name: Methanone, (4-bromophenyl)-2-furanyl-
• CAS NO: 13365-64-5
• Molecular Formula: C11H7BrO2
• Molecular Weight: 251.079
• Mol File: 13365-64-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Methanone, (4-bromophenyl)-2-furanyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-bromophenyl)-2-furanyl-(13365-64-5)
• EPA Substance Registry System: Methanone, (4-bromophenyl)-2-furanyl-(13365-64-5)

Safety Data

• Hazardous Substances Data: 13365-64-5(Hazardous Substances Data)

Upstream product

• 527-69-5 2-furancarbonyl chloride 
• 5467-74-3 4-Bromophenylboronic acid 
• 617-90-3 2-furancarbonitrile 
• 589-21-9 (4-bromophenyl)hydrazine 
• 586-76-5 4-Bromobenzoic acid 
• 118486-94-5 2-(tributylstannyl)furan 
• 586-75-4 4-chlorobenzoyl chloride 
• 110-00-9 furan 
• 108-86-1 bromobenzene 

Relevant articles and documents

Palladium-Catalyzed Denitrogenative Synthesis of Aryl Ketones from Arylhydrazines and Nitriles Using O2 as Sole Oxidant

An efficient and simple palladium-catalyzed approach for the synthesis of aryl ketones from low-cost nitriles and arylhydrazines using molecular oxygen (O2) as sole oxidant via C-N bond cleavage is reported. Various aryl ketones were synthesized in moderate to good yields under mild conditions. A possible mechanism involving the PdII/Pd0 catalytic cycle process is depicted, and a cationic palladium intermediate was detected by ESI-MS.

Palladium-catalyzed chemoselective cross-coupling of acyl chlorides and organostannanes

Chemoselective cross-coupling of aliphatic and aromatic acyl chlorides with aryl-, heteroaryl-, and alkynylstannanes proceeds in up to 98% yield using 2.5 mol % of bis(di-tert-butylchlorophosphine)palladium(II) dichloride as the precatalyst. Various functional groups including aryl chlorides and bromides that usually undergo oxidative addition to palladium complexes bearing phosphinous acid or dialkylchlorophosphine ligands are tolerated. This procedure allows convenient ketone formation and eliminates inherent limitations of Friedel-Crafts acylations such as substituent-directing effects and typical reactivity requirements of Lewis acid-catalyzed electrophilic aromatic substitutions.

Infrared and Nuclear Magnetic Resonance Properties of Benzoyl Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

Benzophenones, 2-benzoylthiophenes, 2-benzoylpyrroles, and 2-benzoylfurans, which have substituents at m- and p-positions of the benzoyl ring were prepared and their ir and nmr spectra were obtained in 0.1 M chloroform-d solution. The chemical shift values of each series were plotted against the Hammett substituent parameters to give good correlation, with the exception of the ortho-Hs and -Cs. The slopes as well as the differences in chemical shift gave sets of meaningful values for the indices of aromaticy.