133765-48-7Relevant articles and documents
3-Aryl-4-isoquinolinone derivatives an efficient oxidative preparation
SanMartin, Raul,Olivera, Roberto,Carrillo, Luisa,Tellitu, Imanol,Badia, Maria Dolores,Dominguez, Esther
, p. 1643 - 1652 (1997)
A comparative study of the oxidation of 3-aryl-4-hydroxytetrahydroisoquinolines has been carried out. A modification of the Jones conditions turn out to be the best methodology for the regioselective preparation of target 4-isoquinolinone derivatives.
A Simple and Efficient Synthetic Route to Benzophenanthridines
Seraphin, Denis,Lynch, Michael A.,Duval, Olivier
, p. 5731 - 5734 (2007/10/02)
The benzophenanthridine nucleus has been prepared in an overall yield of 52-58percent in five stages.Synthetic route employs as key steps the intramolecular cyclisation of vinyl alcohols followed by a novel one pot double oxidation using iodine in etha
Cyclisation of benzylaminonitriles. Part 8. Anhydrous hydrogen fluoride as cyclising agent
Euerby, Melvin R.,Gavin, James P.,Olugbade, Tiwalade A.,Patel, Sanjay S.,Waigh, Roger D.
, p. 545 - 554 (2007/10/02)
The preferred cyclisation pathway for benzylaminonitriles in anhydrous HF is through a spiro intermediate, as it is in sulphuric acid.Unlike sulphuric acid, HF can be used in the cyclisation of N-alkyl benzylaminonitriles to give N-alkyl isoquinolinones a