133841-15-3 Usage
General Description
7-Hydroxygranisetron is a chemical compound that is derived from the antiemetic medication granisetron. It is a serotonin 5-HT3 receptor antagonist, which means it inhibits the action of serotonin on these receptors. This makes it useful in preventing nausea and vomiting, particularly in the setting of chemotherapy or radiation therapy. The hydroxylation of granisetron forms 7-Hydroxygranisetron, which has been found to have even greater potency and efficacy in blocking the serotonin receptors. As a result, 7-Hydroxygranisetron may be a promising candidate for the development of new and improved antiemetic medications.
Check Digit Verification of cas no
The CAS Registry Mumber 133841-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,8,4 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 133841-15:
(8*1)+(7*3)+(6*3)+(5*8)+(4*4)+(3*1)+(2*1)+(1*5)=113
113 % 10 = 3
So 133841-15-3 is a valid CAS Registry Number.
133841-15-3Relevant articles and documents
High-affinity fluorescent ligands for the 5-HT3 receptor
Simonin, Jonathan,Vernekar, Sanjeev Kumar V.,Thompson, Andrew J.,Hothersall, J. Daniel,Connolly, Christopher N.,Lummis, Sarah C.R.,Lochner, Martin
, p. 1151 - 1155 (2012/03/26)
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT3AR.
