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134-11-2 Usage

Chemical Properties

Pale yellow low melting solid

Uses

2-Ethoxybenzoic acid is used in thermally induced solvent-free reactions of triphenylbismuth with a series of thiols and carboxylic acids. It serves as an active component of dental cement. Further, it prevents the entry of root-canal pathogens into periapical regions.

General Description

2-Ethoxybenzoic acid is dental cement. It is root-end filling material and prevents the entry of root-canal pathogens into periapical regions.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 134-11-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 134-11:
(5*1)+(4*3)+(3*4)+(2*1)+(1*1)=32
32 % 10 = 2
So 134-11-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O3/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H,10,11)

134-11-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A14758)  2-Ethoxybenzoic acid, 98%   

  • 134-11-2

  • 25g

  • 181.0CNY

  • Detail
  • Alfa Aesar

  • (A14758)  2-Ethoxybenzoic acid, 98%   

  • 134-11-2

  • 100g

  • 453.0CNY

  • Detail
  • Alfa Aesar

  • (A14758)  2-Ethoxybenzoic acid, 98%   

  • 134-11-2

  • 500g

  • 1816.0CNY

  • Detail

134-11-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Ethoxybenzoic acid

1.2 Other means of identification

Product number -
Other names ethoxybenzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134-11-2 SDS

134-11-2Synthetic route

diethyl sulfate
64-67-5

diethyl sulfate

methyl salicylate
119-36-8

methyl salicylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: diethyl sulfate; methyl salicylate With potassium hydroxide In ethanol at 15℃; for 6h; Large scale;
Stage #2: With water; sodium hydroxide at 65℃; for 6h; Temperature; Large scale;
98.31%
(2-ethoxybenzoylamino)pyridine-1-oxide

(2-ethoxybenzoylamino)pyridine-1-oxide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 80℃; for 10h;81%
With sodium hydroxide In ethanol at 80℃; for 8h;80%
With sodium hydroxide In ethanol at 80℃; for 8h; Temperature; Schlenk technique;80%
ethyl 2-ethoxybenzoate
6290-24-0

ethyl 2-ethoxybenzoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxybenzoate With potassium tert-butylate In dimethyl sulfoxide at 70℃; for 2h;
Stage #2: With hydrogenchloride; water In dimethyl sulfoxide at 0 - 10℃;
80%
With barium dihydroxide
With water
2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With phthalic anhydride; silica gel microwave irradiation;75%
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

A

2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With potassium carbonate
7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

sodium ethanolate
141-52-6

sodium ethanolate

A

1-(4-ethoxy-2-hydroxyphenyl)ethanone
37470-42-1

1-(4-ethoxy-2-hydroxyphenyl)ethanone

B

4-ethoxy-2-hydroxybenzoic acid
10435-55-9

4-ethoxy-2-hydroxybenzoic acid

C

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

diethyl sulfate
64-67-5

diethyl sulfate

methyl salicylate
119-36-8

methyl salicylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: diethyl sulfate; methyl salicylate With potassium hydroxide In ethanol at 15℃; for 6h; Large scale;
Stage #2: With water; sodium hydroxide at 65℃; for 6h; Temperature; Large scale;
98.31%
(2-ethoxybenzoylamino)pyridine-1-oxide

(2-ethoxybenzoylamino)pyridine-1-oxide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 80℃; for 10h;81%
With sodium hydroxide In ethanol at 80℃; for 8h;80%
With sodium hydroxide In ethanol at 80℃; for 8h; Temperature; Schlenk technique;80%
ethyl 2-ethoxybenzoate
6290-24-0

ethyl 2-ethoxybenzoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxybenzoate With potassium tert-butylate In dimethyl sulfoxide at 70℃; for 2h;
Stage #2: With hydrogenchloride; water In dimethyl sulfoxide at 0 - 10℃;
80%
With barium dihydroxide
With water
2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With phthalic anhydride; silica gel microwave irradiation;75%
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

A

2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With potassium carbonate
7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

sodium ethanolate
141-52-6

sodium ethanolate

A

1-(4-ethoxy-2-hydroxyphenyl)ethanone
37470-42-1

1-(4-ethoxy-2-hydroxyphenyl)ethanone

B

4-ethoxy-2-hydroxybenzoic acid
10435-55-9

4-ethoxy-2-hydroxybenzoic acid

C

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

6-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

6-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

sodium ethanolate
141-52-6

sodium ethanolate

A

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

B

5-ethoxy-2-hydroxybenzoic acid
14160-71-5

5-ethoxy-2-hydroxybenzoic acid

C

1-(5-ethoxy-2-hydroxyphenyl)ethanone
56414-14-3

1-(5-ethoxy-2-hydroxyphenyl)ethanone

sodium o-methoxycarbonylphenolate
7631-93-8

sodium o-methoxycarbonylphenolate

ethyl iodide
75-03-6

ethyl iodide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
at 160℃; im geschlossenen Rohr, durch Behandeln mit Barytwasser;
methyl 2-ethoxybenzoate
3686-55-3

methyl 2-ethoxybenzoate

methylamine
74-89-5

methylamine

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

diethyl sulfate
64-67-5

diethyl sulfate

salicylic acid
69-72-7

salicylic acid

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at 20℃; for 40h;
With potassium hydroxide In acetone
carbon dioxide
124-38-9

carbon dioxide

Phenetole
103-73-1

Phenetole

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
(i) nBuLi, THF, hexane, (ii) /BRN= 1900390/; Multistep reaction;
ethyl iodide
75-03-6

ethyl iodide

dipotassium salt of/the/ salicylic acid

dipotassium salt of/the/ salicylic acid

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With ethanol at 100℃; im geschlossenen Rohr; Behandeln mit Alkali;
With ethanol durch Behandeln mit Alkali;
ethyl iodide
75-03-6

ethyl iodide

potassium compound of salicylic acid ethyl ester

potassium compound of salicylic acid ethyl ester

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With ethanol at 100℃; im geschlossenen Rohr; Behandeln mit Alkali;
With ethanol durch Behandeln mit Alkali;
o-ethoxy-cis-cinnamic acid
38624-46-3

o-ethoxy-cis-cinnamic acid

KMnO4

KMnO4

alkali

alkali

A

2-ethoxylbenzaldehyde
613-69-4

2-ethoxylbenzaldehyde

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(E)-3-(2-ethoxyphenyl)prop-2-enoic acid
59923-03-4

(E)-3-(2-ethoxyphenyl)prop-2-enoic acid

potassium permanganate

potassium permanganate

alkali

alkali

A

2-ethoxylbenzaldehyde
613-69-4

2-ethoxylbenzaldehyde

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

alcoholic potash

alcoholic potash

A

2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
im geschlossenen Rohr;
sulfuric acid
7664-93-9

sulfuric acid

2-ethoxy-N-hydroxybenzamide
50357-86-3

2-ethoxy-N-hydroxybenzamide

A

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

B

hydroxylamine
7803-49-8

hydroxylamine

salicylic acid
69-72-7

salicylic acid

o-sulfonbenzoic acid endo-anhydride

o-sulfonbenzoic acid endo-anhydride

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / acetone
2: H2O, alkali
View Scheme
methyl 2-ethoxybenzoate
3686-55-3

methyl 2-ethoxybenzoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With methanol; sodium hydroxide; water at 50℃;
With methanol; sodium hydroxide at 50℃;15.8 g
C9H10O3*C25H31N3O

C9H10O3*C25H31N3O

A

crystal violet carbinol base
467-63-0

crystal violet carbinol base

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
In toluene at 28℃; Kinetics;
2-benzamidopyridine 1-oxide
14178-42-8

2-benzamidopyridine 1-oxide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver(l) oxide; sodium acetate; cobalt(II) diacetate tetrahydrate / 12 h / 60 °C / Schlenk technique
2: sodium hydroxide / ethanol / 10 h / 80 °C
View Scheme
benzoic acid
65-85-0

benzoic acid

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2: silver(l) oxide; sodium acetate; cobalt(II) diacetate tetrahydrate / 12 h / 60 °C / Schlenk technique
3: sodium hydroxide / ethanol / 10 h / 80 °C
View Scheme
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With ethylene glycol; potassium hydroxide Heating;
salicylonitrile
611-20-1

salicylonitrile

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate
2: potassium hydroxide; ethylene glycol / Heating
View Scheme
methyl salicylate
119-36-8

methyl salicylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide / acetone / 0.5 h / 20 °C
1.2: Reflux
2.1: methanol; sodium hydroxide / 50 °C
View Scheme
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxybenzoyl chloride
42926-52-3

2-ethoxybenzoyl chloride

Conditions
ConditionsYield
With phosgene; N,N-dimethyl-formamide In acetone at 50℃;99.7%
With thionyl chloride
With phosphorus pentachloride
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxy-5-chlorosulphonyl-benzoic acid
200575-16-2

2-ethoxy-5-chlorosulphonyl-benzoic acid

Conditions
ConditionsYield
With chlorosulfonic acid; thionyl chloride at 20℃;90.6%
With chlorosulfonic acid; thionyl chloride at 0 - 25℃; for 18h;81%
With chlorosulfonic acid; thionyl chloride In water
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxybenzoic acid hydrazide
21018-13-3

2-ethoxybenzoic acid hydrazide

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere;
Stage #2: With hydrazine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.333333h; Inert atmosphere;
90%
Multi-step reaction with 2 steps
1: thionyl chloride / 0.07 h / Microwave irradiation
2: hydrazine hydrate / 0.05 h / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride
2: hydrazine hydrate
View Scheme
(1R)-endo-(+)-fenchol
2217-02-9

(1R)-endo-(+)-fenchol

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

C19H26O3

C19H26O3

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 5h;90%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

5-bromo-2-ethoxy-benzoic acid
60783-90-6

5-bromo-2-ethoxy-benzoic acid

Conditions
ConditionsYield
With bromine; acetic acid at 25℃;89%
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 48h;
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 48h;
With bromine In acetic acid at 20℃;
C14H16F2N2O3*ClH
1574285-43-0

C14H16F2N2O3*ClH

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

N-({2-[4-(difluoromethoxy)-3-isopropoxyphenyl]oxazole-4-yl}methyl)-2-ethoxybenzamide

N-({2-[4-(difluoromethoxy)-3-isopropoxyphenyl]oxazole-4-yl}methyl)-2-ethoxybenzamide

Conditions
ConditionsYield
Stage #1: C14H16F2N2O3*ClH With triethylamine In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: 2-ethoxybenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate at 20 - 30℃; for 1h;
88.18%
Stage #1: C14H16F2N2O3*ClH With triethylamine In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: 2-ethoxybenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate at 20 - 30℃; for 1h;
72.6%
Stage #1: C14H16F2N2O3*ClH With sodium hydrogencarbonate In water; ethyl acetate at 50℃; for 0.166667h;
Stage #2: 2-ethoxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetone for 1h; Reflux;
18.58 g
Stage #1: C14H16F2N2O3*ClH With triethylamine In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: 2-ethoxybenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate at 20 - 30℃; for 1h;
18.38 g
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide
247583-78-4

4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide

4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide
501120-38-3

4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid With thionyl chloride for 3h; Heating;
Stage #2: 4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide With dmap; triethylamine In benzene for 3h; Heating;
88%
4-toluenesulfonyl azide
941-55-9

4-toluenesulfonyl azide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxy-6-[(4-methylphenyl)sulfonamido]benzoic acid

2-ethoxy-6-[(4-methylphenyl)sulfonamido]benzoic acid

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 50℃; for 24h;88%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

triphenylbismuthane
603-33-8

triphenylbismuthane

tris-2-ethoxybenzoatobismuth

tris-2-ethoxybenzoatobismuth

Conditions
ConditionsYield
In melt byproducts: C6H6; grinding of 2.5 mmol of Ph3Bi and 7.5 mmol 2-ethoxybenzoic acid; placingin a glass vial; heating at 120°C for 3 h; addn. of a small amt. of acetone, pptn., washing, recrystn. from acetoneover 2 w; elem. anal.;87%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

diphenyl acetylene
501-65-5

diphenyl acetylene

(E)-[1-(3-ethoxyphenyl)-1,2-diphenyl]ethene

(E)-[1-(3-ethoxyphenyl)-1,2-diphenyl]ethene

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 100℃; for 24h; Inert atmosphere;87%
2-(2-amino-4-chlorophenoxy)benzeneamine

2-(2-amino-4-chlorophenoxy)benzeneamine

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-(2-(2-ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzeneamine

2-(2-(2-ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzeneamine

Conditions
ConditionsYield
microwave irradiation;85%
4,4'-dimethoxydiphenylacetylene
2132-62-9

4,4'-dimethoxydiphenylacetylene

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(E)-[1-(3-ethoxyphenyl)-1,2-bis-(p-anisyl)]ethene

(E)-[1-(3-ethoxyphenyl)-1,2-bis-(p-anisyl)]ethene

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 100℃; for 24h; Inert atmosphere;84%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one
6458-30-6

2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one

3-(2-ethoxy-1-benzoyl)-2,2-bis(trifluoromethyl)oxazolidinone

3-(2-ethoxy-1-benzoyl)-2,2-bis(trifluoromethyl)oxazolidinone

Conditions
ConditionsYield
With thionyl chloride for 24h; Reflux; Inert atmosphere;82%
oxalyl dichloride
79-37-8

oxalyl dichloride

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

5-amino-1-propyl-1H-imidazole-4-carboxamide
61507-88-8

5-amino-1-propyl-1H-imidazole-4-carboxamide

5-(2-ethoxybenzamido)-1-n-propylimidazole-4-carboxamide
155581-73-0

5-(2-ethoxybenzamido)-1-n-propylimidazole-4-carboxamide

Conditions
ConditionsYield
In pyridine; N-methyl-acetamide; methanol; dichloromethane77%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

triphenylbismuthane
603-33-8

triphenylbismuthane

triphenylbismuth bis(2-ethoxybenozate)

triphenylbismuth bis(2-ethoxybenozate)

Conditions
ConditionsYield
With dihydrogen peroxide In diethyl ether for 0.166667h;76%
1,2-bis(4-methylphenyl)acetylene
2789-88-0

1,2-bis(4-methylphenyl)acetylene

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(E)-{1-(3-ethoxyphenyl)-1,2-bis-[p-tolyl]}ethene

(E)-{1-(3-ethoxyphenyl)-1,2-bis-[p-tolyl]}ethene

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 100℃; for 24h; Inert atmosphere;76%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

methyl iodide
74-88-4

methyl iodide

methyl 2-ethoxy-6-[(triisopropylsilyl)ethynyl]benzoate

methyl 2-ethoxy-6-[(triisopropylsilyl)ethynyl]benzoate

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid; 1-bromo-2-(triisopropylsilyl)acetylene With [Ru(O2CMes)2(p-cymene)] In 1,4-dioxane at 120℃; for 16h; Inert atmosphere; Schlenk technique;
Stage #2: methyl iodide With potassium carbonate In 1,4-dioxane; acetonitrile at 50℃; for 2h; Inert atmosphere; Schlenk technique;
76%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(Z)-methyl 2-fluoro-3-(2-ethoxyphenyl)acrylate

(Z)-methyl 2-fluoro-3-(2-ethoxyphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; diastereoselective reaction;76%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

4H-carabrone
68776-20-5

4H-carabrone

carabryl 2-ethoxybenzoate

carabryl 2-ethoxybenzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h;75%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(S)-(1-(4-(aminomethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

(S)-(1-(4-(aminomethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

(S)-(1-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-4-((2-ethoxybenzylcarbamoyl)methyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

(S)-(1-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-4-((2-ethoxybenzylcarbamoyl)methyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: (S)-(1-(4-(aminomethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester In tetrahydrofuran at 60℃; for 3h;
75%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

salicylic acid
69-72-7

salicylic acid

Conditions
ConditionsYield
With piperazine In N,N-dimethyl acetamide at 150℃; for 12h; Substitution;74%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
103343-47-1

3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

2-ethoxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide

2-ethoxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;72%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

3,3'-diethoxy-1,1'-biphenyl

3,3'-diethoxy-1,1'-biphenyl

Conditions
ConditionsYield
With copper(I) oxide; dipotassium hydrogenphosphate; palladium diacetate; silver carbonate In 1,2-dimethoxyethane at 150℃; for 21h; Inert atmosphere; Sealed tube; regioselective reaction;72%
benzylacrylate
2495-35-4

benzylacrylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

benzyl (E)-3-(3-ethoxyphenyl)acrylate

benzyl (E)-3-(3-ethoxyphenyl)acrylate

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 120℃; for 18h; Inert atmosphere;69%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

phenol
108-95-2

phenol

Conditions
ConditionsYield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N,N,N,-tetramethylethylenediamine; iron at 170℃; for 24h; Inert atmosphere; regioselective reaction;69%
6-ethyl-5,7-dimethyl-2,3-dihydro-1H-2,4,7a,8-tetraaza-cyclopenta[a]indene hydrochloride

6-ethyl-5,7-dimethyl-2,3-dihydro-1H-2,4,7a,8-tetraaza-cyclopenta[a]indene hydrochloride

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(2-ethoxy-phenyl)-(6-ethyl-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]inden-2-yl)-methanone
1444115-37-0

(2-ethoxy-phenyl)-(6-ethyl-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]inden-2-yl)-methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 20℃; for 16h;63%

134-11-2Relevant articles and documents

Copper-mediated direct alkoxylation of arenes using an N, O -bidentate directing system

Zhang, Lin-Bao,Hao, Xin-Qi,Zhang, Shou-Kun,Liu, Ke,Ren, Baozeng,Gong, Jun-Fang,Niu, Jun-Long,Song, Mao-Ping

, p. 10399 - 10409 (2014)

Highly effective CuCl-mediated C-H alkoxylation of arenes and heteroarenes has been developed by using a 2-aminopyridine 1-oxide moiety as an N,O-bidentate directing group. The reaction proceeds smoothly using a broad range of substrates to afford o-alkox

One-Pot Direct Oxidation of Primary Amines to Carboxylic Acids through Tandem ortho-Naphthoquinone-Catalyzed and TBHP-Promoted Oxidation Sequence

Kim, Hun Young,Oh, Kyungsoo,Si, Tengda

supporting information, p. 18150 - 18155 (2021/12/09)

Biomimetic oxidation of primary amines to carboxylic acids has been developed where the copper-containing amine oxidase (CuAO)-like o-NQ-catalyzed aerobic oxidation was combined with the aldehyde dehydrogenase (ALDH)-like TBHP-mediated imine oxidation protocol. Notably, the current tandem oxidation strategy provides a new mechanistic insight into the imine intermediate and the seemingly simple TBHP-mediated oxidation pathways of imines. The developed metal-free amine oxidation protocol allows the use of molecular oxygen and TBHP, safe forms of oxidant that may appeal to the industrial application.

O-ethoxy new synthetic process of formic acid

-

Paragraph 0029; 0036-0040; 0041-0045; 0046-0050, (2019/04/04)

The invention belongs to the technical field of pharmaceutical intermediates, in particular to a O-ethoxy new synthetic process of formic acid. The alcohol into the reaction vessel, adding the solid KOH under stirring conditions, control the reaction temp

A 2-ethoxy carboxylic acid synthetic method of compound

-

Paragraph 0020; 0022, (2017/03/24)

The invention discloses a synthesis method of a 2-ethoxybenzoic acid compound. The synthesis method comprises the following steps of orderly adding aromatic acylaminopyridine-1-oxide, cuprous chloride and an organic solvent into a reactor, stirring the mixture at a room temperature for 25-35min, adding potassium carbonate into the mixture after complex precipitates are produced, heating the reaction system to a temperature of 125-135 DEG C to cause a reaction lasting for 10-15h, after the reaction, carrying out extraction, drying, condensation and chromatographic separation to obtain an ethoxylated product, and carrying out alkaline hydrolysis and acidification to obtain the 2-ethoxybenzoic acid compound. The synthesis method has the advantages of easy acquisition of raw materials, cheap catalyst, mild reaction system, operation simpleness, high yield and substrate universality. The synthesis method has the yield of 87% and can realize guide base removal under mild conditions.

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