134227-41-1

Basic information

• Product Name: Bis(4-fluorobenzyl)aMine, 97%
• Synonyms: Bis(4-fluorobenzyl)aMine, 97%
• CAS NO: 134227-41-1
• Molecular Formula: C₁₄H₁₃F₂N
• Molecular Weight: 233.2565264
• Mol File: 134227-41-1.mol
• Article Data: 33

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Bis(4-fluorobenzyl)aMine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(4-fluorobenzyl)aMine, 97%(134227-41-1)
• EPA Substance Registry System: Bis(4-fluorobenzyl)aMine, 97%(134227-41-1)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 134227-41-1(Hazardous Substances Data)

Usage

General Description

Bis(4-fluorobenzyl)aMine, 97% is a chemical compound that is a derivative of benzylamine, which is commonly used in organic synthesis. This specific compound contains two 4-fluorobenzyl groups, making it useful for applications in drug development, material science, and chemical research. It is known for its high purity of 97%, making it a reliable and desirable option for various laboratory and industrial uses. With its functional groups and high purity, it is a valuable reagent for the production of pharmaceuticals and fine chemicals.

Upstream product

• 824-75-9 p-fluorobenzamide 
• 459-57-4 4-fluorobenzaldehyde 
• 62-53-3 aniline 
• 140-75-0 para-fluorobenzylamine 
• 1194-02-1 4-fluorobenzonitrile 
• 2038-57-5 3-Phenylpropan-1-amine 
• 428819-12-9 N-(4-fluorobenzylidene)-1-(4-fluorophenyl)methanamine 
• 459-23-4 4-fluorobenzaldoxime 
• 78-84-2 isobutyraldehyde 
• 123-72-8 butyraldehyde 
• 123-38-6 propionaldehyde 
• 75-07-0 acetaldehyde 

Downstream Products

• 428819-12-9 N-(4-fluorobenzylidene)-1-(4-fluorophenyl)methanamine 
• 2264-12-2 1-(4-fluorobenzyl)-2-(4-fluorophenyl)-1H-1,3-benzimidazole 
• 1612866-19-9 (S)-2-(bis(4-fluorobenzyl)amino)-N-(tert-butyl)-2-phenylacetamide 
• 1612866-20-2 (R)-2-(bis(4-fluorobenzyl)amino)-N-(tert-butyl)-2-phenylacetamide 

Relevant articles and documents

Supramolecular daisy chains

Two series of self-complementary daisy chain monomers, in which a secondary ammonium ion-containing arm is grafted onto a macrocycle with either a [24]- or [25]crown-8 constitution, have been synthesized. In the solid- and 'gas'-phases, the parent [24]crown-8-based monomer forms dimeric superstructures, as revealed by X-ray crystallography and mass spectrometry, respectively. Elucidation of the complicated solution-phase behavior of this compound was facilitated by the synthesis and study of both deuterated, and fluorinated, analogues. These investigations revealed that the cyclic dimeric superstructure also dominates in solution, except when extremes of either concentration (low), temperature (high), or solvent polarity (highly polar, e.g., dimethyl sulfoxide) are employed. Whereas, upon aggregation, the [24]crown-8-based daisy chain monomers have the capacity to form stereoisomeric superstructures further complicating the study of this series of compounds. The assembly of [25]crown-8-based monomers gives only achiral superstructures. The weaker association exhibited between secondary dialkylammonium ions and crown ethers with a [25]crown-8 constitution, however, resulted in limited oligomerization-only dimeric and trimeric superstructures were formed at experimentally attainable concentrations-of [25]crown-8-based daisy chain monomers.

Tandem Fe/Zn or Fe/In Catalysis for the Selective Synthesis of Primary and Secondary Amines?via Selective Reduction of Primary Amides

Tandem iron/zinc or iron/indium-catalysed reductions of various primary amides to amines under hydrosilylation conditions are reported under visible light activation. By a simple modification of the nature of the co-catalyst (Zn(OTf)2 vs In(OTf)3), Fe(CO)4(IMes) can promote the highly chemoselective reduction of primary amides into primary amines (21 examples, up to 93 % isolated yields) and secondary amines (8 examples, up to 51 % isolated yields), respectively. Notably, both benzamide and alkanamide derivatives can be reduced.

Platinum Nanoparticles Uniformly Dispersed on Covalent Organic Framework Supports for Selective Synthesis of Secondary Amines

Covalent organic frameworks (COFs) with pore structures are talented supports for active components. In this report, COF has been rationally fabricated and served as host for growing uniformly dispersed platinum nanoparticles with a narrow size distribution (2 nm). The obtained hybrid Pt/COF exhibits high catalytic activity in the reductive amination of benzaldehyde towards secondary amines with a yield of 96 % and good recyclability. The preferable selectivity towards secondary amines could be attributed to synergistic effects of active platinum nanoparticles and COF, in which metallic Pt nanoparticles were uniformly dispersed with a positively charged surface. This work will open an avenue towards controlling the interaction between active metals and support as well as rational design of catalysts for demanding transformations for fine agrochemicals intermediates.

Chemoselective transfer hydrogenation of nitriles to secondary amines with nickel(II) catalysts

Herein we report the selective transfer hydrogenation (TH) of nitriles to secondary (2°) amines with simple Ni(II)-catalysts using ammonia borane (AB) as a source of hydrogen (H2). A bis(pyrazolylmethyl)pyridine (L1) or ethylenediamine (L4) ligated Ni(II) pre-catalyst, created in situ, could hydrogenate several aromatic- and aliphatic nitriles in full conversions and isolated yields of up to 88% under ambient temperature and in very short reaction times. Deuterium labelling experiments illustrated the incorporation of a proton on the nitrogen and hydride on the α-carbon of dibenzylamine. Using α-picoline borane, containing no dissociable protons, assisted with the postulation of a two-step TH mechanism of benzonitrile. AB was subjected to dehydrogenation and it was observed that a maximum of 2.96 equivalents of H2 gas could be generated from NiCl2?6H2O/L1.