134287-58-4

Basic information

• Product Name: 3,9-dihydro-3-((1,3-dihydroxy-2-propoxy)methyl)-6-methyl-9-oxo-5H-imidazol(1,2-a)purine
• Synonyms: 3,9-dihydro-3-((1,3-dihydroxy-2-propoxy)methyl)-6-methyl-9-oxo-5H-imidazol(1,2-a)purine
• CAS NO: 134287-58-4
• Molecular Formula: C12H15 N5 O4
• Molecular Weight: 293.28
• Mol File: 134287-58-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 642.7°C at 760 mmHg
• Flash Point: 342.5°C
• Appearance: /
• Density: 1.69g/cm³
• Vapor Pressure: 2.14E-17mmHg at 25°C
• Refractive Index: 1.754
• CAS DataBase Reference: 3,9-dihydro-3-((1,3-dihydroxy-2-propoxy)methyl)-6-methyl-9-oxo-5H-imidazol(1,2-a)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,9-dihydro-3-((1,3-dihydroxy-2-propoxy)methyl)-6-methyl-9-oxo-5H-imidazol(1,2-a)purine(134287-58-4)
• EPA Substance Registry System: 3,9-dihydro-3-((1,3-dihydroxy-2-propoxy)methyl)-6-methyl-9-oxo-5H-imidazol(1,2-a)purine(134287-58-4)

Safety Data

• Hazardous Substances Data: 134287-58-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15N5O4/c1-7-2-17-11(20)9-10(15-12(17)14-7)16(5-13-9)6-21-8(3-18)4-19/h2,5,8,18-19H,3-4,6H2,1H3,(H,14,15)

Upstream product

• 82410-32-0 ganciclovir 
• 598-31-2 1-bromoacetone 

Relevant articles and documents

Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogues of acyclovir and ganciclovir

9-[(2-Hydroxyethoxy)methyl]guanine (acyclovir, 1a) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG, ganciclovir, 1b) were transformed to their respective tricyclic derivatives, 3-substituted 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines 2b, 3a, and 3b. The 6-methyl-substituted compound 2b was obtained following reaction of 1b with bromoacetone. A two-step approach via 1-(2,2-diethoxyethyl) intermediates 4a,b was the most effective for the preparation of the derivatives unsubstituted in the appended ring (3a,b). The novel acyclonucleosides, in particular ganciclovir derivative 2b, proved markedly active against herpes simplex virus type 1 and 2, varicella-zoster virus, and cytomegalovirus.