13450-67-4

Basic information

• Product Name: 4-(2-PIPERIDINOETHYL) PYRIDINE
• Synonyms: 4-(2-piperidinoethyl)-pyridin;4-(beta-piperidinoethyl)pyridine;4-(2-PIPERIDINOETHYL) PYRIDINE;4-[2-(piperidyl)ethyl]pyridine;4-(2-(Piperidin-1-yl)ethyl)pyridine
• CAS NO: 13450-67-4
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• EINECS: 236-607-4
• Mol File: 13450-67-4.mol

Chemical Properties

• Boiling Point: 296.2 °C at 760 mmHg
• Flash Point: 132.9 °C
• Appearance: /
• Density: 1.006 g/cm³
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.531
• PKA: 8.92±0.10(Predicted)
• CAS DataBase Reference: 4-(2-PIPERIDINOETHYL) PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PIPERIDINOETHYL) PYRIDINE(13450-67-4)
• EPA Substance Registry System: 4-(2-PIPERIDINOETHYL) PYRIDINE(13450-67-4)

Safety Data

• Hazardous Substances Data: 13450-67-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-(2-Piperidinoethyl) pyridine is used as a building block for the synthesis of various pharmaceuticals and agricultural chemicals. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Coordination Chemistry:
In coordination chemistry, 4-(2-Piperidinoethyl) pyridine serves as a ligand, forming complexes with metal ions. These complexes exhibit interesting properties and are useful in various applications, such as catalysis and materials science.
Used in Pharmaceutical Research:
4-(2-Piperidinoethyl) pyridine is used as a precursor for the synthesis of other functionalized pyridine derivatives, which are often found in biologically active compounds. Its potential biological activities, including antifungal and antimicrobial properties, make it a promising candidate for the development of new drugs.
Used in Antifungal Applications:
4-(2-Piperidinoethyl) pyridine is used as an antifungal agent, exhibiting activity against various fungal species. Its ability to inhibit fungal growth makes it a valuable component in the development of antifungal medications and treatments.
Used in Antimicrobial Applications:
4-(2-Piperidinoethyl) pyridine also demonstrates antimicrobial properties, making it useful in the development of antimicrobial agents. Its potential to combat bacterial infections contributes to its significance in pharmaceutical research and development.

InChI:InChI=1/C12H18N2/c1-2-9-14(10-3-1)11-6-12-4-7-13-8-5-12/h4-5,7-8H,1-3,6,9-11H2

Upstream product

• 110-89-4 piperidine 
• 100-43-6 4-vinylpyridine 

Downstream Products

• 14759-09-2 1-(2-(piperidin-4-yl)ethyl)piperidine 

Relevant articles and documents

The catalytic effect of anion-exchanged supported ionic liquid on aza-Michael-type addition

Abstract: An effective synthesis of anion-exchanged supported ionic liquids using diatomaceous earth as solid support and its catalytic effect on the aza-Michael-type addition is described. Anionic polytungstophosphate and bisulfate ion are used in the anion-exchange step in catalyst design. In addition, the aza-Michael-type addition of various amines to 2- and 4-vinyl pyridine was examined in this article. The catalytic system can be separated from the reaction mixture and recycled in subsequent reactions. The structure of anion-exchanged supported ionic liquid on diatomaceous earth was studied by XRD, FT-IR, SEM, TGA and BET techniques. The structure of organic products was determined by 1HNMR, 13CNMR, FTIR, CHN and MASS spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].

Aza-Michael-type addition reaction catalysed by a supported ionic liquid phase incorporating an anionic heteropoly acid

In this work, we have obtained substituted amines under mild conditions in good yields using the Aza-Michael-type addition of various amines to vinyl compounds catalysed by a supported ionic liquid incorporating an anionic heteropoly acid. Different catalysts, including Lewis acids, Br?nsted acids and heteropoly acids were investigated in which heteropoly acids having dual Br?nsted and Lewis acid characteristics were excellent catalysts. The ionic liquid incorporating a polytungstate anion supported on magnetic diatomaceous earth as a magnetically separable heterogeneous catalyst offered the best results in terms of yield. The solid nanocatalyst was easily removed with a magnet.

Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition

A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.

Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain

The present invention concerns novel benzenesulphonamide compounds, defined by formula I and the description, their method of preparation and their use in therapy.

Anti-Markonikov reactions, 6. Rhodium-catalyzed amination of vinylpyridines: Hydroamination versus oxidative amination

Cationic rhodium complexes catalyze the amination of 2- and 4- vinylpyridine with secondary amines. Depending on the substrate and the reaction conditions either oxidative amination to yield the corresponding enamines 1a-8a or hydroamination to give 2-aminoethylpyridines 1b-8b occurs. In all cases products with anti-Markovnikov regioselectivity are obtained. For mechanistic studies novel cationic complexes of rhodium(I)-containing cyclooctadiene and vinylpyridine 12 as well as complexes containing cyclooctadiene, vinylpyridine, and morpholine 13 were prepared and characterized by NMR spectroscopy and X-ray diffraction analysis.