1345992-44-0

Basic information

• Product Name: N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide
• Synonyms: N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide
• CAS NO: 1345992-44-0
• Molecular Weight: 471.43
• Mol File: 1345992-44-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide(1345992-44-0)
• EPA Substance Registry System: N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide(1345992-44-0)

Safety Data

• Hazardous Substances Data: 1345992-44-0(Hazardous Substances Data)

Upstream product

• 85-42-7 1,2-Cyclohexanedicarboxylic acid-anhydride 
• 68350-64-1 potassium 3-cyano-1-ethoxy-1-oxobut-2-en-2-olate 
• 5446-18-4 2,4-dichlorophenyl hydrazine hydrochloride 
• 51555-65-8 cyclohexane-1,2-dicarbaldehyde 
• 3971-29-7 1,2-bis(hydroxymethyl)cyclohexane 
• 1345992-78-0 1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydro-2H-isoindol-2-yl)-1H-pyrazole-3-carboxylic acid 
• 108-91-8 cyclohexylamine 
• 1345992-68-8 ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydro-2H-isoindol-2-yl)-1H-pyrazole-3-carboxylate 
• 1015765-46-4 ethyl 5-amino-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate 

Relevant articles and documents

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands

New 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as cannabinoid (CB) receptor ligands. Compound 11 (CB1 Ki = 2.3 nM, CB1 SI = 163.6) showed CB1 receptor affinity and selectivity superior to Rimonabant and AM251. Acute administration of 2 mg/kg 11 reduced sucrose, but not regular food, intake in rats. On the other hand, compound 23 (CB2 Ki = 0.51 nM, CB2 SI = 30.0) showed significant affinity and selectivity for the CB2 receptor. The results presented here show that the 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3- carboxamide may serve as an effective scaffold for the design of either CB 1 or CB2 receptor ligands.