Welcome to LookChem.com Sign In|Join Free

Cas Database

134872-85-8

134872-85-8

134872-85-8

Identification

Synonyms:5-phenylmorpholin-2-one;2-morpholinone, 5-phenyl-;5-Phenylmorpholin-2-on;R-5-Phenyl-morpholin-2-one;

Post Buying Request Now

Chemical Properties

  • Boiling Point: 364.33 °C at 760 mmHg

  • Flash Point:174.141 °C

  • Density: 1.149 g/cm3

  • Storage Temp.:2-8°C

  • Vapor Pressure: 0mmHg at 25°C

  • Refractive Index: 1.535

  • PSA: 38.33000

  • LogP: 1.20290

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Crysdot
  • Product Description:5-Phenylmorpholin-2-one 95+%
  • Packaging:1g
  • Price:$ 772
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:5-phenylmorpholin-2-one 95%
  • Packaging:1g
  • Price:$ 729
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-PHENYL-2-MORPHOLINONE 95.00%
  • Packaging:5MG
  • Price:$ 497.89
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Alichem
  • Product Description:5-Phenylmorpholin-2-one
  • Packaging:1g
  • Price:$ 671.96
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 11 Articles be found

A mild approach to synthesise enantiopure glycine-derived 5-phenylthiomorpholinone

Monir, Diana K.,Harwood, Laurence M.

, (2021)

A seven-step synthetic route has been developed to access the labile C-3 unsubstituted 5-phenylthiomorpholinone system for the first time. The key step involved the nucleophilic ring opening of Boc-phenylmorpholinone to give the corresponding methyl ester. The sulfur introduction was accomplished through a Mitsunobu reaction to yield a thioacetate, which was then hydrolysed to provide the thiol acid. Cyclization of the thiol acid was achieved using DCC in the presence of DMAP, to give Boc-phenylthiomorpholinone and subsequent deprotection afforded the elusive C-3 unsubstituted 5-phenylthiomorpholinone.

Method for preparing tartrate EGS

-

Paragraph 0075; 0076; 0077, (2017/07/31)

The invention discloses a method for preparing tartrate EGS. The method comprises the following steps: (1) subjecting EGS-A4 represented by a formula shown in the description and trifluoroacetic acid to a reduction reaction in an inert atmosphere in the presence of a catalyst, so as to obtain EGS-SMA represented by a formula shown in the description after the reaction is complete, wherein the catalyst is Pd/C or the like; (2) preparing EGS-SMB represented by a formula shown in the description from EGS-B0 represented by a formula shown in the description, an acid binding agent and EGS-B0' represented by a formula shown in the description, then, subjecting the EGS-SMB to a reaction with the EGS-SMA so as to obtain EGS-API represented by a formula shown in the description, and then, subjecting the EGS-API to a reaction with L-tartaric acid, thereby obtaining the final product. The method can adapt to large-scale production processes and has the process characteristics of wide source, low cost and stable yield, and the yield of the obtained tartrate EGS is remarkably higher than that of the existing methods and can reach 95%, so that the method has an important application value.

METHODS FOR TREATING CHRONIC PAIN USING 3-ARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES, 3-HETEROARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

-

Page/Page column 168, (2010/11/29)

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using compounds of Formulas 1 and 2 wherein the variables have the meaning disclosed in the specification

Process route upstream and downstream products

Process route

phenyl 2-bromoacetate
620-72-4

phenyl 2-bromoacetate

(2S)-2-phenylglycinol
20989-17-7

(2S)-2-phenylglycinol

(5S)-5-phenylmorpholin-2-one
144896-92-4,134872-85-8

(5S)-5-phenylmorpholin-2-one

Conditions
Conditions Yield
75%
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 24h;
70%
With N-ethyl-N,N-diisopropylamine; In acetonitrile; Inert atmosphere;
53%
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at -5 - 20 ℃; for 20.5h; Inert atmosphere;
53%
(2S)-2-phenylglycinol; With N-ethyl-N,N-diisopropylamine; In acetonitrile;
phenyl 2-bromoacetate; In acetonitrile; at 20 ℃; for 3.75h;
(S)-5-phenylmorpholin-2-one hydrochloride
491833-36-4

(S)-5-phenylmorpholin-2-one hydrochloride

(5S)-5-phenylmorpholin-2-one
144896-92-4,134872-85-8

(5S)-5-phenylmorpholin-2-one

Conditions
Conditions Yield
With sodium hydrogencarbonate; In ethyl acetate; for 0.5h;
86%
(5S)-N-(benzyloxycarbonylaminomethyl)-5-phenylmorpholin-2-one
197167-72-9

(5S)-N-(benzyloxycarbonylaminomethyl)-5-phenylmorpholin-2-one

(5S)-5-phenylmorpholin-2-one
144896-92-4,134872-85-8

(5S)-5-phenylmorpholin-2-one

(5S)-4-methyl-5-phenylmorpholin-2-one

(5S)-4-methyl-5-phenylmorpholin-2-one

Conditions
Conditions Yield
With hydrogen; palladium; In ethyl acetate; under 760 Torr;
42%
21%
(2S)-2-phenylglycinol
20989-17-7

(2S)-2-phenylglycinol

(5S)-5-phenylmorpholin-2-one
144896-92-4,134872-85-8

(5S)-5-phenylmorpholin-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4.5 h / 5 - 20 °C
1.2: 0.33 h / 15 °C / pH < 2
2.1: sodium hydrogencarbonate / ethyl acetate / 0.5 h
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In ethyl acetate; acetonitrile;
(5S)-5-phenylmorpholin-2-one
144896-92-4,134872-85-8

(5S)-5-phenylmorpholin-2-one

Conditions
Conditions Yield
86%
phenyl 2-bromoacetate
620-72-4

phenyl 2-bromoacetate

D-2-phenylglycinol
56613-80-0

D-2-phenylglycinol

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one
121269-45-2,134872-85-8

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 18h; Ambient temperature;
78%
With N-ethyl-N,N-diisopropylamine; In acetonitrile;
24%
With N-ethyl-N,N-diisopropylamine; In acetonitrile;
(5S)-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one
175226-64-9

(5S)-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one
121269-45-2,134872-85-8

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h; under 760 Torr; Yield given; Ambient temperature;
D-2-phenylglycinol
56613-80-0

D-2-phenylglycinol

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one
121269-45-2,134872-85-8

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 91 percent
2: 72 percent / selenium dioxide / dioxane / 2 h / Heating
3: hydrogen / 10percent Pd-C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
With selenium(IV) oxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate;
(R)-2-methyl-4-phenyl-Δ<sup>2</sup>-oxazoline
116173-81-0

(R)-2-methyl-4-phenyl-Δ2-oxazoline

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one
121269-45-2,134872-85-8

(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 72 percent / selenium dioxide / dioxane / 2 h / Heating
2: hydrogen / 10percent Pd-C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
With selenium(IV) oxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate;
6-methoxy-3-pyridinecarboxaldehyde
65873-72-5

6-methoxy-3-pyridinecarboxaldehyde

(5S)-5-phenylmorpholin-2-one
144896-92-4,134872-85-8

(5S)-5-phenylmorpholin-2-one

(1R,3S,5S)-1,3-bis(6-methoxypyridin-3-yl)-5-phenyltetrahydro-3H,8H-oxazolo[4,3-c][1,4]oxazin-8-one

(1R,3S,5S)-1,3-bis(6-methoxypyridin-3-yl)-5-phenyltetrahydro-3H,8H-oxazolo[4,3-c][1,4]oxazin-8-one

Conditions
Conditions Yield
In toluene; at 152 ℃; for 19h; Dean-Stark; Inert atmosphere;
50.2%

134872-85-8 Upstream products

134872-85-8 Downstream products

Global suppliers and manufacturers

Global( 13) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • Skyrun Industrial Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-576-84610586
  • Emails:sales@chinaskyrun.com
  • Main Products:17
  • Country:China (Mainland)
  • PRIME MOLECULAR CO.,LIMITED
  • Business Type:Trading Company
  • Contact Tel:0852-0755-61104662
  • Emails:sales@prime-molecular.com
  • Main Products:1
  • Country:China (Mainland)
  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 134872-85-8
Post Buying Request Now
close
Remarks: The blank with*must be completed
Submit