135206-76-7

Basic information

• Product Name: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE
• Synonyms: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE;3-(Chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride
• CAS NO: 135206-76-7
• Molecular Formula: C₄H₆ClN₃*ClH
• Molecular Weight: 131.56
• Mol File: 135206-76-7.mol

Chemical Properties

• Boiling Point: 255.3 °C at 760 mmHg
• Flash Point: 108.2 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 0.0164mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE(135206-76-7)
• EPA Substance Registry System: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE(135206-76-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 135206-76-7(Hazardous Substances Data)

Usage

Uses

3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride is a useful research chemical.

InChI:InChI=1/C4H6ClN3/c1-8-3-6-4(2-5)7-8/h3H,2H2,1H3

Upstream product

• 91616-36-3 1-methyl-1H-[1,2,4]-(triazol-5-yl)methanol 
• 135242-93-2 (1-methyl-1H-[1,2,4]-triazol-3-yl)methanol 

Downstream Products

• 731817-71-3 2-{8-fluoro-3-[4-fluoro-3-(1-methyl-1H-[1,2,4]triazol-3-ylmethoxy)phenyl]imidazo[1,2-c]pyrimidin-7-yl}propan-2-ol 
• 342652-75-9 5-Hydroxymethyl-3-(1-methyl-1H-[1,2,4]triazol-3-ylmethoxy)-4-phenylpyrazole 
• 497850-26-7 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 783331-24-8 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine 
• 497850-19-8 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-methyl-1H-1,2,4-triazol-5-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 265642-78-2 3-bromo-7-(2-fluorophenyl)-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine 
• 344791-91-9 5-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline 
• 344791-93-1 5-(1,1-dimethylethyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 344792-01-4 5-bromo-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 344791-96-4 6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-ylamine 
• 327985-57-9 3,8-bis(2-fluorophenyl)-5-methyl-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)imidazo[1,2-d][1,2,4]triazine 
• 265643-68-3 5-hydroxymethyl-3-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-4-phenylpyrazole 
• 252750-10-0 6-(1,1-dimethylethyl)-5-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,3-triazolo[4,5-b]pyridine 
• 252750-22-4 5-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,3-triazolo[4,5-c]isoquinoline 

Relevant articles and documents

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In an effort to find potent antifungal agents, optically active sulfur- containing triazole derivatives, sulfides (3) and sulfonamides (4), were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo. The sulfides (3) were prepared by the reaction of (2R,3R)- 2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1) with various heteroarylmethyl chlorides in the presence of sodium methoxide. The sulfonamides (4) were synthesized starting from the disulfide (15) in three steps including oxidation of the corresponding sulfenamides (17). Some of the sulfur-containing triazole derivatives (3, 4) showed strong protective effects against candidosis in mice.

Heteroaryliumthio substituted carbapenem derivatives: Synthesis and in vitro activity of 1β-methyl-2-(dihydropyrrolotriazoliumthio)carbapenems

The syntheses of five thiols, including three dihydropyrrolotriazoliumthiol salts, 1,4-dimethyl-5-mercaptomethyl-1,2,4-triazolium trifluoromethanesulfonate, and 6-mercapto-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazolium chloride; and the addition of these thiols to 4-nitrobenzyl (IR,5R,6S)-2-(diphenylphosphono)oxy-6-[1(R)-hydroxyethyl]-1-methylcarbapen-2-cm -3-carboxylate and the subsequent hydrogenolysis of the addition products is described. The latter thiol provides a new route towards the preparation of L-627 (LJC 10,627). The compounds were evaluated in vitro against a panel of Gram-positive and Gram-negative bacteria and their antibacterial activities compared with imipenem. The compounds were measured for their hydrolytic stability to dehydropeptidase I (DHP-I) relative to imipenem. The five compounds generally had poorer Gram-positive and Pseudomonas activity than imipenem, although their Gram negative activity was variably improved. The monocyclic triazolium analog was nearly comparable in overall activity to the four bicyclic heterarylium analogs evaluated, including L-627 (LJC 10,627), All compounds were more stable to DHP-I than imipenem, although minor differences existed among them.

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1,2,4-TRIAZOLE-3,5-DIAMINE DERIVATIVES

The invention relates to compounds of the formula (I) STR1 and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR 1 and R 2 represent hydrogen, an aliphatic or cycloaliphatic group, or R 1 and R 2 together with the nitrogen atom form a 5 to 10 membered heterocyclic ring:Alk represents a straight or branched alkylene chain;Q represents furan, thiophen or benzene ring which is incorporated into the rest of the molecule; X represents--CH 2--, STR2--O--or--S--where R 6 represents hydrogen or methyl;n represents zero, 1 or 2; m represents 2, 3 or 4;R 3 represents hydrogen, a substituted or unsubstituted aliphatic or aryl group and;R 4 and R 5, which may be the same or different, each represent hydrogen, a substituted or unsubstituted aliphatic, aryl, or together with the nitrogen atom form a heterocyclic group.