135273-60-8Relevant articles and documents
Solid phase cross-coupling reaction of aryl(halo)silanes with 4-iodobenzoic acid
Homsi, Fadi,Hosoi, Kazushi,Nozaki, Kyoko,Hiyama, Tamejiro
, p. 208 - 216 (2007/10/03)
Aryl(alkyl)(halo)silanes undergo facile and efficient palladium catalyzed cross-coupling reaction with iodobenzoic acid tethered to the Wang resin. Acid cleavage releases unsymmetrical biaryl carboxylic acids with high conversions, purities and yields.
CARBONYLATIVE COUPLING REACTION OF ORGANOFLUOROSILANES WITH ORGANIC HALIDES PROMOTED BY FLUORIDE ION AND PALLADIUM CATALYST
Hatanaka, Yasuo,Fukushima, Satoshi,Hiyama, Tamejiro
, p. 2113 - 2126 (2007/10/02)
Palladium-catalyzed carbonylative cross coupling reaction of organofluorosilanes with organic halides was achieved in the presence of fluoride ion and an atmospheric pressure of carbon monoxide.Alkenyl- or arylfluorosilanes effectively underwent this reaction with alkenyl or aryl iodides in moderate to good yields.Thus, highly functionalized ketones are readily available without protection of reactive functional group such as aldehyde, ketone, ester, nitril, and alcohol.For smooth ketone formation, use of organofluorosilanes is essential; tetraorganosilanes like aryl(trimethyl)silanes, upon reaction with aryl iodides, gave aroyl fluorides instead. Key Words: carbonylative coupling; organofluorosilanes; ketone synthesis