135638-82-3

Basic information

• Product Name: N-(tert-butoxycarbonyl)-N-(3,6,9-trioxadecyl)-O-benzylhydroxylamine
• Synonyms: N-(tert-butoxycarbonyl)-N-(3,6,9-trioxadecyl)-O-benzylhydroxylamine
• CAS NO: 135638-82-3
• Molecular Weight: 369.458
• Mol File: 135638-82-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(tert-butoxycarbonyl)-N-(3,6,9-trioxadecyl)-O-benzylhydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butoxycarbonyl)-N-(3,6,9-trioxadecyl)-O-benzylhydroxylamine(135638-82-3)
• EPA Substance Registry System: N-(tert-butoxycarbonyl)-N-(3,6,9-trioxadecyl)-O-benzylhydroxylamine(135638-82-3)

Safety Data

• Hazardous Substances Data: 135638-82-3(Hazardous Substances Data)

Upstream product

• 62921-74-8 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 
• 79722-21-7 tert-butyl N-(benzyloxy)carbamate 

Downstream Products

• 135638-83-4 N-(3,6,9-trioxadecyl)-O-benzylhydroxylamine 
• 135638-88-9 33-(tert-butoxycarbonyl)-11,22,33-tris(benzyloxy)-12,15,23,26-tetraoxo-11,16,22,27,33-pentaaza-2,5,8-trioxatritriacontane 
• 135658-21-8 11,22,33-tris(benzyloxy)-12,15,23,26,34-pentaoxo-11,16,22,27,33-pentaaza-2,5,8,36,39,42-hexaoxatritetracontane 
• 135638-90-3 11,22,33-tris(benzyloxy)-12,15,23,26,34-pentaoxo-11,16,22,27,33-pentaaza-2,5,8-trioxapentatriacontane 
• 135638-89-0 11,22,33-tris(benzyloxy)-12,15,23,26-tetraoxo-11,16,22,27,33-pentaaza-2,5,8-trioxatritriacontane 
• 135638-85-6 22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane 
• 135638-87-8 5,16-bis(benzyloxy)-4,12,15-trioxo-5,11,16-triaza-19,22,25-trioxahexacosanoic acid 
• 135638-86-7 11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane 
• 135638-84-5 N-(benzyloxy)-N-(3,6,9-trioxadecyl)succinamic acid 

Relevant articles and documents

Synthesis and biological evaluation of hydroxamate-based iron chelators

A new and versatile route to desferrioxamine B (DFO, 1) is described. Hydroxamate reagent 4 was elaborated in a series of high yield steps to the tert-butoxycarbonyl nitrile 11, which provided DFO in three transformations. The intermediate 11 could also be utilized in the preparation of DFO analogues which contain terminal N-acyl groups other than acetyl. The methodology was further employed in the syntheses of the DFO polyether analogues 2 and 3, beginning with the 3,6,9-trioxadecylation of N-(tert- butoxycarbonyl)-O-benzylhydroxylamine. Polyethers 2 and 3 are neutral molecules, which are somewhat more lipophilic than the parent DFO. Polyether hydroxamate 2 was shown to be nearly 3 times as effective as desferrioxamine at clearing iron in rats.