136-64-1Relevant articles and documents
Design, synthesis and spectroscopic characterization of metal (II) complexes derived from a tetradentate macrocyclic ligand: Study on?antimicrobial and antioxidant capacity of complexes
Gull, Parveez,Malik, Manzoor Ahmad,Dar, Ovas Ahmad,Hashmi, Athar Adil
, p. 212 - 216 (2017)
The paper presents the synthesis of Co(II), Ni(II) and Cu(II) complexes of macrocyclic Schiff base ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and ethyl 3-oxobutanoate (2:2). The synthesized ligand and its metal complexes were characterized by elemental analyses, magnetic susceptibility measurements, FTIR, UV–Vis., mass 1H NMR and X-ray diffraction. The Cu(II) complex exhibit distorted octahedral geometry, whereas an octahedral geometry is suggested for other complexes. The synthesized compounds were screened in?vitro for their antimicrobial activities to evaluate their inhibiting potential against bacterial species Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and fungal species include Aspergillus flavus, Aspergillus fumingatus, and Candida albicans. The complexation led to a remarkable increase in antimicrobial activity. In addition, the antioxidant activity of the compounds was also investigated through scavenging effect on DPPH radicals. The obtained IC50 value of the DPPH activity for the copper complex was higher than other compounds.
Biological activity studies on metal complexes of macrocyclic Schiff base ligand: Synthesis and spectroscopic characterization
Gull, Parveez,Hashmi, Athar Adil
, p. 1331 - 1337 (2015)
In this study, we prepared the macrocyclic Schiff base ligand (L) derived from 1,4-dicarbonylphenyl-dihydrazide and pentane-2,4-dione (2:2) and its CoII, CuII and NiII complexes. The compounds were characterized by the analytical and spectroscopic methods like elemental analysis, molar conductance measurements, mass spectrometry,1 H nuclear magnetic resonance (NMR), and Fourier transform infrared (FTIR) spectroscopy. The ligand behaves as a tetradentate ligand and coordinates to the metal ions via the nitrogen atoms and the complexes have the mononuclear structures. The analytical and spectroscopic results indicated that the complexes are non-electrolytes in nature and may be formulated as [M(C26H28 N8 O4)X2], where M = CoII, CuII and NiII and X = Cl-. The antimicrobial activities of the ligand and its complexes, as growth inhibiting agents, have been screened in vitro against different species of bacteria and fungi and the results concluded that the metal complexes are effective drugs against the tested strains as compared to the macrocyclic ligand.
Mechanosynthesis of imine, β-ketoenamine, and hydrogen-bonded imine-linked covalent organic frameworks using liquid-assisted grinding
Das, Gobinda,Balaji Shinde, Digambar,Kandambeth, Sharath,Biswal, Bishnu P.,Banerjee, Rahul
, p. 12615 - 12618 (2014)
A variety of aromatic amines/hydrazides and aldehydes have been utilized for the construction of crystalline COFs at a faster rate and in high yield, irrespective of their reactivity and solubility using the Liquid-Assisted Grinding (LAG) method.
Synthesis of Schiff base 24-membered trivalent transition metal derivatives with their anti-inflammation and antimicrobial evaluation
Kumar, Gajendra,Devi, Shoma,Kumar, Dharmendra
, p. 680 - 688 (2016)
The paper presents the synthesis of macrocyclic complexes [{M(C52H36N12O4)X}X2] of Cr(III), Mn(III) and Fe(III) with Schiff base ligand (C52H36N12O4) obtained through the condensation of 1,4-dicarbonyl phenyl dihydrazide with 1,2-di(1H-indol-1-yl)ethane-1,2-dione. The newly formed Schiff base and its complexes have been characterized with the help of elemental analysis, condensation measurements, magnetic measurements and their structure configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. The electronic spectra of the complexes indicate a five coordinate square pyramidal geometry of the center metal ion. These metal complexes and ligand were tested for their anti-inflammation and antimicrobial inhibiting potential and compared with standard drugs Phenyl butazone (anti-inflammation), Imipenem (antibacterial) and Miconazole (antifungal).
Preparation, regulation and biological application of a Schiff base fluorescence probe
Yin, Ninghua,Diao, Haipeng,Liu, Wen,Wang, Jingru,Feng, Liheng
, p. 1 - 5 (2016)
A facile fluorescence switch with Schiff base units was designed and achieved by nucleophilic addition and dehydration reaction. The fluorescence of the probe can be regulated by metal ions (Al3 + and Cu2 +). The whole process shows that the weak fluorescence of the probe enhances with the addition of Al3 +, and then the strong fluorescence of the probe/Al3 + ensemble reduces by introducing Cu2 +. Meanwhile, the solution color changes of the probe with metal ions can be observed under 365 nm UV-vis light from weak light, pale green, green, pale green to weak light. Noticeably, the photo regulation processes of the probe by metal ions can be realized in the biological system and applied in cells imaging. The work provides a new strategy for designing facile regulation probe and develops a new application for Schiff base derivatives.
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cr (III), Mn (III) and Fe (III) macrocyclic complexes
Kumar, Gajendra,Devi, Shoma,Johari, Rajeev,Kumar, Dharmendra
, p. 269 - 274 (2012)
A Schiff base ligand was synthesized by reacting 1,4-dicarbonyl-phenyl- dihydrazide and chromene-2,3-dione (2:2) and a series of metal complexes with this new ligand were synthesized by reaction with Cr (III), Mn (III), and Fe (III) metal salt in methanolic medium. The Schiff base ligand and its metal complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structure configuration has been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic spectra of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential.
FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
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Paragraph 0175; 0186-0187; 0228; 0232-0234, (2021/06/22)
The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.
Linkage Engineering by Harnessing Supramolecular Interactions to Fabricate 2D Hydrazone-Linked Covalent Organic Framework Platforms toward Advanced Catalysis
Qian, Cheng,Zhou, Weiqiang,Qiao, Jingsi,Wang, Dongdong,Li, Xing,Teo, Wei Liang,Shi, Xiangyan,Wu, Hongwei,Di, Jun,Wang, Hou,Liu, Guofeng,Gu, Long,Liu, Jiawei,Feng, Lili,Liu, Yuchuan,Quek, Su Ying,Loh, Kian Ping,Zhao, Yanli
supporting information, p. 18138 - 18149 (2020/11/02)
Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers with tailor-made structures and functionalities. To facilitate their utilization for advanced applications, it is crucial to develop a systematic approach to control the properties of COFs, including the crystallinity, stability, and functionalities. However, such an integrated design is challenging to achieve. Herein, we report supramolecular strategy-based linkage engineering to fabricate a versatile 2D hydrazone-linked COF platform for the coordination of different transition metal ions. Intra- and intermolecular hydrogen bonding as well as electrostatic interactions in the antiparallel stacking mode were first utilized to obtain two isoreticular COFs, namely COF-DB and COF-DT. On account of suitable nitrogen sites in COF-DB, the further metalation of COF-DB was accomplished upon the complexation with seven divalent transition metal ions M(II) (M = Mn, Co, Ni, Cu, Zn, Pd, and Cd) under mild conditions. The resultant M/COF-DB exhibited extended π-conjugation, improved crystallinity, enhanced stability, and additional functionalities as compared to the parent COF-DB. Furthermore, the dynamic nature of the coordination bonding in M/COF-DB allows for the easy replacement of metal ions through a postsynthetic exchange. In particular, the coordination mode in Pd/COF-DB endows it with excellent catalytic activity and cyclic stability as a heterogeneous catalyst for the Suzuki-Miyaura cross-coupling reaction, outperforming its amorphous counterparts and Pd/COF-DT. This strategy provides an opportunity for the construction of 2D COFs with designable functions and opens an avenue to create COFs as multifunctional systems.
