1362804-75-8

Basic information

• Product Name: tert-butyl 3-(benzyl(methyl)amino)azetidine-1-carboxylate
• Synonyms: tert-butyl 3-(benzyl(methyl)amino)azetidine-1-carboxylate
• CAS NO: 1362804-75-8
• Molecular Weight: 276.379
• Mol File: 1362804-75-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-(benzyl(methyl)amino)azetidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(benzyl(methyl)amino)azetidine-1-carboxylate(1362804-75-8)
• EPA Substance Registry System: tert-butyl 3-(benzyl(methyl)amino)azetidine-1-carboxylate(1362804-75-8)

Safety Data

• Hazardous Substances Data: 1362804-75-8(Hazardous Substances Data)

Upstream product

• 454703-20-9 3-methylaminoazetidine-1-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 193269-78-2 3-aminoazetidine-1-carboxylic acid tert-butyl ester 
• 939760-33-5 tert-butyl 3-(benzylamino)azetidine-1-carboxylate 
• 74-88-4 methyl iodide 
• 100-52-7 benzaldehyde 

Downstream Products

• 1383372-67-5 C₁₁H₁₆N₂*ClH 

Relevant articles and documents

Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities

Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine.

NOVEL N- (4- (AZETIDINE - 1 - CARBONYL) PHENYL) - (HETERO - ) ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS

Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of canc