136436-87-8

Basic information

• Product Name: Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine
• CAS NO: 136436-87-8
• Molecular Weight: 339.425
• Mol File: 136436-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine(136436-87-8)
• EPA Substance Registry System: Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine(136436-87-8)

Safety Data

• Hazardous Substances Data: 136436-87-8(Hazardous Substances Data)

Upstream product

• 825-83-2 4-trifluoromethylbenzenethiol 
• 79130-51-1 3-chloro-N,N-dimethyl-3-phenylpropan-1-amine 

Downstream Products

• 128036-38-4 UN⁽¹⁰⁰⁾C₁₀₀₁₆A 

Relevant articles and documents

POTENTIAL ANTIDEPRESSANTS: 3-ARYL-3-(ARYLTHIO)PROPYLAMINES AS SELECTIVE INHIBITORS OF 5-HYDROXYTRYPTAMINE RE-UPTAKE IN THE BRAIN

4-(Trifluoromethyl)thiophenol, 2-methylthiophenol, 2-methoxythiophenol, and 1-naphthalene-thiol were transformed by reactions with N,N-dimethyl-3-chloro-3-phenylpropylamine to N,N-dimethyl-3-aryl-3-(arylthio)propylamines IVa-VIIa.These afforded the secondary amines IVb-VIIb by treatment with ethyl chloroformate and by the following hydrolysis and decarboxylation of the primarily formed N-(methyl)N-(ethoxycarbonyl) analogues.Reaction of 1-naphthalenethiol with the 4-toluenesulfonic ester X in situ gave the thiophene analogue VIIIa which was similarly demethylated to VIIIb.Some of the prepared compounds (IVa, IVb, Va, VIIIa) were found to be selective inhibitors of 5-hydroxytryptamine re-uptake in the rat brain synaptosomes which indicates their potential antidepressant activity.