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137-32-6

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137-32-6 Usage

General Description

2-Methyl-1-butanol, also known as active amyl alcohol, is a clear, colorless liquid at room temperature with a characteristic odor. It is classified as a secondary alcohol and is one of the isomers of amyl alcohol. It is used in the production of various chemicals, pharmaceuticals, and in flavor and fragrance applications due to its fruity odor. It is also a common solvent for various reactions and can be found in a variety of industrial products. 2-Methyl-1-butanol, being flammable, requires careful handling and can cause irritation when contact is made with eyes or skin. It is also harmful if ingested or inhaled.

Check Digit Verification of cas no

The CAS Registry Mumber 137-32-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 137-32:
(5*1)+(4*3)+(3*7)+(2*3)+(1*2)=46
46 % 10 = 6
So 137-32-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H12O/c1-3-5(2)4-6/h5-6H,3-4H2,1-2H3/t5-/m0/s1

137-32-6 Well-known Company Product Price

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  • Alfa Aesar

  • (B21825)  (±)-2-Methyl-1-butanol, 98%   

  • 137-32-6

  • 100ml

  • 153.0CNY

  • Detail
  • Alfa Aesar

  • (B21825)  (±)-2-Methyl-1-butanol, 98%   

  • 137-32-6

  • 500ml

  • 320.0CNY

  • Detail
  • Alfa Aesar

  • (B21825)  (±)-2-Methyl-1-butanol, 98%   

  • 137-32-6

  • 2500ml

  • 880.0CNY

  • Detail

137-32-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methylbutan-1-ol

1.2 Other means of identification

Product number -
Other names 2-Methyl-1-butanol,natural

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137-32-6 SDS

137-32-6Synthetic route

2-methylenesuccinic acid
97-65-4

2-methylenesuccinic acid

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

2-methyl-1,4-butandiol
2938-98-9

2-methyl-1,4-butandiol

Conditions
ConditionsYield
With hydrogen In water at 130℃; under 37503.8 Torr; for 30h; Pressure; Reagent/catalyst; Autoclave;A 10%
B 87%
2-Methyl-1-butene
563-46-2

2-Methyl-1-butene

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
Stage #1: 2-Methyl-1-butene With diborane In dichloromethane at -16℃; for 0.0833333h; hydroboration;
Stage #2: With dihydrogen peroxide In sodium hydroxide Oxidation;
86%
With diethylene glycol dimethyl ether Behandeln einer Loesung des Reaktionsprodukts in wasserhaltigem Aether mit wss.Natronlauge und mit wss.Wasserstoffperoxid;
With sodium hydroxide; samarocene; dihydrogen peroxide; benzo[1,3,2]dioxaborole 1.) THF, benzene, 20 deg C, 14 h, 2.) THF, benzene; Yield given. Multistep reaction;
Stage #1: 2-Methyl-1-butene In 1,4-dioxane at 20℃;
Stage #2: With alkaline hydrogen peroxide In 1,4-dioxane Further stages.;
2-Methylbutyraldehyde
96-17-3, 57456-98-1

2-Methylbutyraldehyde

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With isopropyl alcohol; zirconium(IV) oxide for 6h; Rate constant; Heating;80%
With isopropyl alcohol; zirconium(IV) oxide for 6h; Heating;80%
With sodium cyanoborohydride; 1,1,1,3,3,3-hexamethyl-disilazane; ytterbium(III) triflate In tetrahydrofuran; acetonitrile at 20℃; for 72h; Inert atmosphere;32%
carbon monoxide
201230-82-2

carbon monoxide

butan-1-ol
71-36-3

butan-1-ol

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With [Mn(HN(C2H4PiPr2)2)(CO)2Br]; hydrogen; sodium t-butanolate In toluene at 150℃;66%
1,4-dioxane
123-91-1

1,4-dioxane

ethylacrolein
922-63-4

ethylacrolein

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

2-ethyl-2-methyl-1,3-propanediol
77-84-9

2-ethyl-2-methyl-1,3-propanediol

Conditions
ConditionsYield
With formaldehyd; hydroquinoneA 61.5%
B n/a
4-penten-3-one
1629-58-9

4-penten-3-one

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

2-ethyl-2-methyl-1,3-propanediol
77-84-9

2-ethyl-2-methyl-1,3-propanediol

Conditions
ConditionsYield
With sodium hydroxide; formaldehyd; hydroquinone In 1,4-dioxane; ethanolA 55.7%
B n/a
carbon monoxide
201230-82-2

carbon monoxide

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

di-2-butyl ether
6863-58-7

di-2-butyl ether

Conditions
ConditionsYield
With hydrogen; Cobalt rhodium; iodine at 200℃; under 420 Torr; for 2h; Product distribution; other promoter, other pressure;A 34%
B 1%
1,3,5-Trioxan
110-88-3

1,3,5-Trioxan

sec-butylmagnesium bromide
671795-46-3

sec-butylmagnesium bromide

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

methanol
67-56-1

methanol

ethanol
64-17-5

ethanol

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With aluminum oxide; hydrogen; magnesium oxide; copper(II) oxide at 260℃; unter gewoehnlichem Druck;
With aluminum oxide; hydrogen; magnesium oxide; copper(II) oxide at 350℃; under 22065.2 Torr;
With aluminum oxide; hydrogen; magnesium oxide; copper(II) oxide at 260℃; unter gewoehnlichem Druck;
With aluminum oxide; hydrogen; magnesium oxide; copper(II) oxide at 350℃; under 22065.2 Torr;
formaldehyd
50-00-0

formaldehyd

sec-butylmagnesium bromide
671795-46-3

sec-butylmagnesium bromide

A

formaldehyde-[bis-(2-methyl-butyl)-acetal]
412013-41-3

formaldehyde-[bis-(2-methyl-butyl)-acetal]

B

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With diethyl ether Behandeln des Reaktionsgemisches mit wss.Schwefelsaeure;
formaldehyd
50-00-0

formaldehyd

sec-butylmagnesium bromide
671795-46-3

sec-butylmagnesium bromide

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

1-chloro-2-methylbutane
616-13-7

1-chloro-2-methylbutane

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With glyceride alkali salt; water Hydrolysis;
2-Methylbutyraldehyde
96-17-3, 57456-98-1

2-Methylbutyraldehyde

A

2-Methylbutanoic acid
116-53-0, 600-07-7

2-Methylbutanoic acid

B

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
bei der Einw. von Bacterium xylinum in Gegenwart von Allylsenfoel als Desinficiens;
bei der Einw. von B. ascendens in Gegenwart von Allylsenfoel als Desinficiens;
bei der Einw. von Pferdeleberbrei in Gegenwart von Allylsenfoel als Desinficiens;
2-methylbut-2-enal
497-03-0

2-methylbut-2-enal

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With iron; acetic acid
With nickel kieselguhr at 200℃; under 73550.8 Torr; Hydrogenation;
ethyl 2-methylbutyrate
7452-79-1

ethyl 2-methylbutyrate

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 6h;
2-methyl-2-buten-1-ol
497-02-9, 19319-26-7, 4675-87-0

2-methyl-2-buten-1-ol

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With platinum(IV) oxide Hydrogenation;
With nickel at 80℃; Hydrogenation.unter Druck;
2-methyl-2-pentenal
1115-11-3

2-methyl-2-pentenal

A

2-Methylbutyraldehyde
96-17-3, 57456-98-1

2-Methylbutyraldehyde

B

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With nickel kieselguhr at 200℃; under 73550.8 Torr;
isobutylamide
541-46-8

isobutylamide

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With ethanol; sodium
Ethyl isovalerate
108-64-5

Ethyl isovalerate

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With CuO/Cr2O3 at 250℃; under 110326 - 147102 Torr; Hydrogenation;
diethyl 2-ethyl-2-methylmalonate
2049-70-9

diethyl 2-ethyl-2-methylmalonate

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With chromium oxide-copper oxide barium oxide catalyst at 250℃; Hydrogenation.unter Druck;
Multi-step reaction with 2 steps
1: lithium chloride / dimethyl sulfoxide; water / 10 h / 150 °C / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C
View Scheme
s-butyl bromide
78-76-2, 5787-31-5

s-butyl bromide

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With carbon disulfide; diethyl ether; magnesium man fuegt zu der Reaktionsloesung Polyoxymethylen;
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With chromium oxide-copper oxide barium oxide catalyst at 250℃; Hydrogenation.unter Druck;
formaldehyd
50-00-0

formaldehyd

sodium butanolate
2372-45-4

sodium butanolate

butan-1-ol
71-36-3

butan-1-ol

A

methanol
67-56-1

methanol

B

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

C

2-Methylene-1-butanol
4435-54-5

2-Methylene-1-butanol

Conditions
ConditionsYield
at 120℃;
ethyloxirane
106-88-7

ethyloxirane

methyl iodide
74-88-4

methyl iodide

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

2,2-dimethyl-propanol-1
75-84-3

2,2-dimethyl-propanol-1

Conditions
ConditionsYield
With hydrogenchloride; Ni(PPh3)2 1) room temp., 50 h; Yield given. Multistep reaction. Yields of byproduct given;
With hydrogenchloride; tetrakis(triphenylphosphine)nickel(0) 1) room temp., 50 h; Yield given. Multistep reaction. Yields of byproduct given;
2-Methylbutanoic acid
116-53-0, 600-07-7

2-Methylbutanoic acid

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride
With hydrogen In hexane at 130℃; under 15001.5 Torr; for 18h; Molecular sieve; chemoselective reaction;70 %Chromat.
trans-2-Butene
624-64-6

trans-2-Butene

carbon monoxide
201230-82-2

carbon monoxide

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With sodium tetrahydroborate; hydrogen; acetylacetonato(1,5-cyclooctadiene)rhodium(I); phosphite 4a autoclave, 1.) PhH, 70 deg C, 8 h; 2.) THF/H2O, 0 deg C, 1 h; Yield given. Multistep reaction;
methyl 2-methylbutanoate
868-57-5

methyl 2-methylbutanoate

1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene
31469-16-6

1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

3-Hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester

3-Hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; diisobutylaluminium hydride 1) CH2Cl2/toluene, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 1 h; Yield given. Multistep reaction;
methyl 2-methylbutanoate
868-57-5

methyl 2-methylbutanoate

1-phenoxy-1-trimethylsilyloxyethene
111061-31-5

1-phenoxy-1-trimethylsilyloxyethene

A

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

B

3-Hydroxy-4-methyl-hexanoic acid phenyl ester

3-Hydroxy-4-methyl-hexanoic acid phenyl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; diisobutylaluminium hydride 1) CH2Cl2/toluene, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 1 h; Yield given. Multistep reaction;
1-(2-Chloro-ethoxy)-2-methyl-butane

1-(2-Chloro-ethoxy)-2-methyl-butane

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With potassium Sodium In diethyl ether Yield given;
2-methyl butyrate
5749-49-5

2-methyl butyrate

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

Conditions
ConditionsYield
With carbon monoxide; Paraquat In water at 40℃; pH: 5.5; Clostridium thermoaceticum;
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

p-toluenesulfonic acid 2-methylbutyl ester
63526-71-6

p-toluenesulfonic acid 2-methylbutyl ester

Conditions
ConditionsYield
With pyridine at 0 - 5℃; for 3h;100%
With pyridine100%
With pyridine In dichloromethane at 0℃; for 1h; Inert atmosphere; Sonication;95%
3,3-Dimethylacryloyl chloride
3350-78-5

3,3-Dimethylacryloyl chloride

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2-methylbutyl 3-methyl-2-butenoate

2-methylbutyl 3-methyl-2-butenoate

Conditions
ConditionsYield
With pyridine; dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.5h;100%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

isopentanoyl chloride
108-12-3

isopentanoyl chloride

2‐methylbutyl isovalerate
2445-77-4

2‐methylbutyl isovalerate

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane at 0 - 20℃; for 2.5h;99.7%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

ethyl acetate
141-78-6

ethyl acetate

2-methylbutyl acetate
624-41-9

2-methylbutyl acetate

Conditions
ConditionsYield
sodium hydrogen sulfate; silica gel for 1h; Heating;99%
With Novozyme-435 at 20℃; for 48h; Time; Sealed tube; Enzymatic reaction;
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2,6-dichloro-4,8-bis(piperidin-1-yl)pyrimido[5,4-d]pyrimidine
7139-02-8

2,6-dichloro-4,8-bis(piperidin-1-yl)pyrimido[5,4-d]pyrimidine

2,6-bis-(2-methyl-butoxy)-4,8-di-piperidin-1-yl-pyrimido[5,4-d]pyrimidine

2,6-bis-(2-methyl-butoxy)-4,8-di-piperidin-1-yl-pyrimido[5,4-d]pyrimidine

Conditions
ConditionsYield
Stage #1: (+/-)-2-methyl-1-butanol With sodium hydride In tetrahydrofuran at 60℃; for 0.0833333h;
Stage #2: 2,6-dichloro-4,8-bis(piperidin-1-yl)pyrimido[5,4-d]pyrimidine In tetrahydrofuran Heating;
98%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

isobutyric Acid
79-31-2

isobutyric Acid

2-pentyl 2-methylpropanoate

2-pentyl 2-methylpropanoate

Conditions
ConditionsYield
With Rhizomucor miehei lipase In n-heptane at 40℃; for 24h; Enzymatic reaction;97.7%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

propionic acid
802294-64-0

propionic acid

1-methylbutyl propanoate
54004-43-2

1-methylbutyl propanoate

Conditions
ConditionsYield
With Rhizomucor miehei lipase In n-heptane at 40℃; for 24h; Enzymatic reaction;97.4%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

butyric acid
107-92-6

butyric acid

(RS)-2-pentyl butyrate
60415-61-4

(RS)-2-pentyl butyrate

Conditions
ConditionsYield
With Rhizomucor miehei lipase In n-heptane at 40℃; for 24h; Enzymatic reaction;97.2%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

valeric acid
109-52-4

valeric acid

2-pentyl valerate
89155-38-4

2-pentyl valerate

Conditions
ConditionsYield
With Rhizomucor miehei lipase In n-heptane at 40℃; for 24h; Enzymatic reaction;97.1%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

(S)-(-)-3,3,3-Trifluormilchsaeure
125995-00-8

(S)-(-)-3,3,3-Trifluormilchsaeure

2-methylbutyl 3,3,3-trifluoro-2-hydroxypropionate

2-methylbutyl 3,3,3-trifluoro-2-hydroxypropionate

Conditions
ConditionsYield
In benzene Esterification; Heating;97%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

acetic acid
64-19-7

acetic acid

2-Pentyl acetate
626-38-0

2-Pentyl acetate

Conditions
ConditionsYield
With Rhizomucor miehei lipase In n-heptane at 40℃; for 24h; Enzymatic reaction;96.3%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

1-methyl-1-phenylethyl alcohol
617-94-7

1-methyl-1-phenylethyl alcohol

[1-methyl-1-(2-methyl-butoxy)-ethyl]-benzene

[1-methyl-1-(2-methyl-butoxy)-ethyl]-benzene

Conditions
ConditionsYield
With bismuth(III) bromide In tetrachloromethane at 25℃; for 0.0833333h; Etherification;96%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

L-Tartaric acid
87-69-4

L-Tartaric acid

poly(ethylene glycol) monomethyl ether

poly(ethylene glycol) monomethyl ether

poly(ethylene glycol) monomethyl ether, MW 2000 Da, ester with 2-methylbutyl L-tartrate

poly(ethylene glycol) monomethyl ether, MW 2000 Da, ester with 2-methylbutyl L-tartrate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 115℃; for 45h;96%
phthalic anhydride
85-44-9

phthalic anhydride

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

phthalic acid bis-(2-methyl-butyl ester)
42925-80-4

phthalic acid bis-(2-methyl-butyl ester)

Conditions
ConditionsYield
With sulfonated graphene In toluene at 112℃; for 4h;96%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2-amino-6-chloropurine
10310-21-1

2-amino-6-chloropurine

6-(2-methyl-butoxy)-9H-purin-2-ylamine

6-(2-methyl-butoxy)-9H-purin-2-ylamine

Conditions
ConditionsYield
Stage #1: (+/-)-2-methyl-1-butanol With sodium hydride at 20℃; for 0.5h;
Stage #2: 2-amino-6-chloropurine at 70℃;
96%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

1-Phenylethanol
98-85-1, 13323-81-4

1-Phenylethanol

(α-methylbenzyl) (2-ethyl-1-hexyl) ether

(α-methylbenzyl) (2-ethyl-1-hexyl) ether

Conditions
ConditionsYield
With bismuth(III) bromide In tetrachloromethane at 25℃; for 0.25h; Etherification;95%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2-<(trimethylsilyl)methyl>-1-cyclohexenemethanol
133728-38-8

2-<(trimethylsilyl)methyl>-1-cyclohexenemethanol

2-methyl-1-(4,5,6,7-tetrahydroisobenzofuran-1-yl)butan-1-one

2-methyl-1-(4,5,6,7-tetrahydroisobenzofuran-1-yl)butan-1-one

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; trimethylphosphine(hexafluoroacetylacetone)copper; Selectfluor In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile at 100℃; for 10h; Reagent/catalyst; Solvent;94.1%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2-(2-Methyl-butoxy)-tetrahydro-pyran

2-(2-Methyl-butoxy)-tetrahydro-pyran

Conditions
ConditionsYield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 0.216667h; Neat (no solvent);94%
With Envirocat EPZG at 0 - 5℃; for 0.333333h;87%
quinazolin-2-ylamine
1687-51-0

quinazolin-2-ylamine

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

N-(2-methylbutyl)quinazolin-2-amine
1421970-35-5

N-(2-methylbutyl)quinazolin-2-amine

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide In neat (no solvent) at 150℃; for 12h; Schlenk technique; Inert atmosphere; regioselective reaction;94%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

L-Tartaric acid
87-69-4

L-Tartaric acid

C14H24O4

C14H24O4

Conditions
ConditionsYield
With per-rhenic acid In water at 170℃; for 1h; Inert atmosphere;94%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

acryloyl chloride
814-68-6

acryloyl chloride

2-methylbutyl acrylate
44914-03-6, 32215-41-1

2-methylbutyl acrylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 23℃; for 30h;93%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

citric acid
77-92-9

citric acid

tri-n-active amyl citrate

tri-n-active amyl citrate

Conditions
ConditionsYield
With sulfonated graphene In toluene at 112℃; for 4h;93%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

4-ethoxy-2,2,5,8,8-pentamethyl-6-methylene-3,7-dioxa-2,8-disilanon-4-ene
124851-69-0

4-ethoxy-2,2,5,8,8-pentamethyl-6-methylene-3,7-dioxa-2,8-disilanon-4-ene

ethyl 5-hydroxy-2,6-dimethyl-3-oxooctanoate

ethyl 5-hydroxy-2,6-dimethyl-3-oxooctanoate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In tetrahydrofuran at -78℃; for 2h; Mukaiyama Aldol Addition; Inert atmosphere;93%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

ethyl (7E)-7,9-decadienoate

ethyl (7E)-7,9-decadienoate

2-methylbutyl (7E)-7,9-decadienoate

2-methylbutyl (7E)-7,9-decadienoate

Conditions
ConditionsYield
With potassium tert-butylate at 20 - 40℃; for 5.66667h;92.5%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2‐methylbutyl 2‐methylbutanoate
2445-78-5

2‐methylbutyl 2‐methylbutanoate

Conditions
ConditionsYield
With N-Bromosuccinimide; L-proline In water at 20℃; for 3h;92%
With pyridinium hydrobromide perbromide In water at 20℃; for 14h;90%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; ortho-nitrofluorobenzene In toluene at 115℃; for 20h; Schlenk technique; Sealed tube;70%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

thianthrene cation radical perchlorate
35787-71-4

thianthrene cation radical perchlorate

A

thianthrenium perchlorate

thianthrenium perchlorate

B

5-(2-Methyl-butoxy)-thianthren-5-ium; perchlorate

5-(2-Methyl-butoxy)-thianthren-5-ium; perchlorate

Conditions
ConditionsYield
In dichloromethane for 1h; Ambient temperature;A n/a
B 92%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

cyclohexanone
108-94-1

cyclohexanone

(2-methyl-butoxy)-cyclohexane

(2-methyl-butoxy)-cyclohexane

Conditions
ConditionsYield
With molecular sieve; hydrogen; platinum on activated charcoal In chloroform at 50℃; under 750.06 Torr; for 2h;92%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

N-(2-methylbutyl)-4-methylbenzenesulfonamide
109950-07-4

N-(2-methylbutyl)-4-methylbenzenesulfonamide

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium tert-butylate In toluene for 17h; Inert atmosphere; Reflux;92%
(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

(+-)-2-methylbutyl 4-chlorobenzoate

(+-)-2-methylbutyl 4-chlorobenzoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;92%
2-Methylbutanoic acid
116-53-0, 600-07-7

2-Methylbutanoic acid

(+/-)-2-methyl-1-butanol
137-32-6

(+/-)-2-methyl-1-butanol

2‐methylbutyl 2‐methylbutanoate
2445-78-5

2‐methylbutyl 2‐methylbutanoate

Conditions
ConditionsYield
With pyridine; dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.5h;91.9%

137-32-6Related news

Production of 2-Methyl-1-butanol (cas 137-32-6) in engineered Escherichia coli09/30/2019

Recent progress has been made in the production of higher alcohols by harnessing the power of natural amino acid biosynthetic pathways. Here, we describe the first strain of Escherichia coli developed to produce the higher alcohol and potential new biofuel 2-methyl-1-butanol (2MB). To accomplish...detailed

Volumetric and ultrasonic study of mixtures of 2-phenylethanol with 1-butanol, 2-butanol, and 2-Methyl-1-butanol (cas 137-32-6) at T=(298.15–323.15) K and atmospheric pressure: Measurement and prediction10/01/2019

Densities and speeds of sound for three binary mixtures 2-phenylethanol with 1-butanol, 2-butanol and 2-methyl-1-butanol were measured over the entire range of composition and at six temperatures from 298.15K to 323.15K at 5K interval and atmospheric pressure using a vibrating tube densimeter. B...detailed

137-32-6Relevant articles and documents

Highly selective hydrogenation of CO2 into C2+ alcohols by homogeneous catalysis

Qian, Qingli,Cui, Meng,He, Zhenhong,Wu, Congyi,Zhu, Qinggong,Zhang, Zhaofu,Ma, Jun,Yang, Guanying,Zhang, Jingjing,Han, Buxing

, p. 5685 - 5689 (2015)

The hydrogenation of CO2 to produce alcohols with two or more carbons (C2+ alcohols) is of great importance, but is challenging. In this work, we found that a Ru3(CO)12/Rh2(CO)4Cl2-LiI system could catalyze the reaction effectively in 1,3-dimethyl-2-imidazolidinone (DMI) under mild conditions. Methanol, ethanol, propanol, 2-methyl propanol, butanol, and 2-methyl butanol were produced in the homogeneous catalytic reaction. The C2+ alcohols could be generated at 160 °C, which is the lowest temperature reported so far for producing C2+ alcohols via CO2 hydrogenation. The selectivity for the C2+ alcohols could be as high as 96.4% at the optimized conditions, which is higher than those reported in the literature. In addition, the catalytic system could be easily recycled. The route of the reaction for forming the C2+ alcohols was discussed on the basis of control experiments.

Substrate profiling and aldehyde dismutase activity of the Kvβ2 subunit of the mammalian Kv1 potassium channel

Alka, Kumari,Ryan, Barry J.,Dolly, J. Oliver,Henehan, Gary T.M.

, p. 2012 - 2018 (2010)

Voltage-dependent potassium channels (Kv) are involved in various cellular signalling processes by governing the membrane potential of excitable cells. The cytosolic face of these α subunit-containing channels is associated with β subunits that can modulate channel responses. Surprisingly, the β subunit of the mammalian Kv1 channels, Kvβ2, has a high level of sequence homology with the aldo-keto reductase (AKR) superfamily of proteins. Recent studies have shown that Kvβ2 can catalyze the reduction of aldehydes and, most significantly, that channel function is modulated when Kvβ2-bound NADPH is concomitantly oxidized. As a result, the redox chemistry of this subunit is crucial to understanding its role in K+ channel modulation. The present study has extended knowledge of the substrate profile of this subunit using a single turnover fluorimetric assay. Kvβ2 was found to catalyse the reduction of aromatic aldehyde substrates such as 2, 3 and 4-nitrobenzaldehydes, 4-hydroxybenzaldehyde, pyridine 2-aldehyde and benzaldehyde. The presence of an electron withdrawing group at the position para to the aldehyde in aromatic compounds facilitated reduction. Aliphatic aldehydes proved to be poor substrates. We devised a simple HPLC-based assay to identify Kvβ2 reaction products. Using this assay we showed, for the first time, that Kvβ2 can catalyze a slow aldehyde dismutation reaction using 4-nitrobenzaldehyde as substrate and have identified the products of this reaction. The ability of Kvβ2 to carry out both an aldehyde reduction and a dismutation reaction is discussed in the light of current thinking on the role of redox chemistry in channel modulation.

Uranyl(VI) Triflate as Catalyst for the Meerwein-Ponndorf-Verley Reaction

Kobylarski, Marie,Monsigny, Louis,Thuéry, Pierre,Berthet, Jean-Claude,Cantat, Thibault

supporting information, p. 16140 - 16148 (2021/11/01)

Catalytic transformation of oxygenated compounds is challenging in f-element chemistry due to the high oxophilicity of the f-block metals. We report here the first Meerwein-Ponndorf-Verley (MPV) reduction of carbonyl substrates with uranium-based catalysts, in particular from a series of uranyl(VI) compounds where [UO2(OTf)2] (1) displays the greatest efficiency (OTf = trifluoromethanesulfonate). [UO2(OTf)2] reduces a series of aromatic and aliphatic aldehydes and ketones into their corresponding alcohols with moderate to excellent yields, using iPrOH as a solvent and a reductant. The reaction proceeds under mild conditions (80 °C) with an optimized catalytic charge of 2.3 mol % and KOiPr as a cocatalyst. The reduction of aldehydes (1-10 h) is faster than that of ketones (>15 h). NMR investigations clearly evidence the formation of hemiacetal intermediates with aldehydes, while they are not formed with ketones.

Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation

Kaithal, Akash,H?lscher, Markus,Leitner, Walter

, p. 976 - 982 (2021/02/06)

A catalytic reaction using syngas (CO/H2) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex [Mn(CO)2Br[HN(C2H4PiPr2)2]]1comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install methyl branches at sp3carbon centers utilizing renewable feedstocks and energy for the synthesis of biologically active compounds, fine chemicals, and advanced biofuels.

METHOD FOR PRODUCING ALCOHOL

-

Paragraph 0101-0110, (2020/11/26)

PROBLEM TO BE SOLVED: To provide a method for producing selectively alcohol from carboxylic acid under mild conditions. SOLUTION: In the presence of a catalyst with M1 and M2 as metal species supported on a support, a substrate is reduced to produce a corresponding alcohol. (M1 is Rh, Pt, Ru, Ir, or Pd; M2 is Sn, V, Mo, W, or Re; the support is ZrO2, hydroxyapatite, Nb2O5, fluoroapatite, or hydrotalcite; the substrate is the formula 1a, 1b, or 1c). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPO&INPIT

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