137081-41-5

Usage

Uses

1-Fluorocyclopropane-1-carboxylic acid

Upstream product

• 63141-10-6 1-(1-fluorocyclopropyl)ethanone 
• 154985-93-0 (1-fluorocyclopropyl)methanol 
• 22059-21-8 aminocyclopropane-1-carboxylic acid 

Downstream Products

• 149961-53-5 1-fluorocyclopropane-1-carbonyl chloride 
• 137081-15-3 N-(2-methoxy-5-pyridyl)-1-fluorocyclopropanecarboxamide 

Relevant academic research and scientific papers

Intramolecular hydrogen bonding in (1-fluorocyclopropyl)methanol as studied by microwave spectroscopy and quantum chemical calculations

(1-Fluorocyclopropyl)methanol has been studied by microwave spectroscopy in the 12-61GHz spectral region. The rotational spectra of the ground and of four vibrationally excited states belonging to three different normal modes of one rotamer have been assi

Preparation method of 1-fluorocyclopropane carboxylic acid

The invention discloses a preparation method of 1-fluorocyclopropane carboxylic acid. The preparation method comprises the following steps: dissolving 1-aminocyclopropane carboxylic acid in a fluorination reagent, adding a diazotization reagent, and reacting at -78 to 150 DEG C for 8-36 hours to obtain 1-fluorocyclopropane carboxylic acid. According to the preparation method of 1-fluorocyclopropane carboxylic acid, the 1-aminocyclopropane carboxylic acid is reacted with the diazotization reagent, diazotization is carried out, and reaction with the diazotization reagent is adopted, so that 1-fluorocyclopropane carboxylic acid is rapidly and efficiently prepared through a simple one-step process; 1-aminocyclopropane carboxylic acid, the fluorination reagent and the diazotization reagent areused as raw materials, the cost of the raw materials is low, reaction conditions are easy to control, and the method is suitable for large-scale production; the reaction yield reaches 38%, the processis simple, and pollution is not likely to be caused.

3-substituted acrylic acid compound as well as preparation method and application thereof

The invention provides a 3-substituted acrylic acid compound as well as a preparation method and application thereof and in particular relates to a 3-substituted acrylic acid compound, a stereoisomer,a pro-drug, a hydrate or pharmaceutically acceptable salt or ester thereof, and a pharmaceutical composition thereof as well as a preparation method and application thereof. The compound provided bythe invention can inhibit activity of an estrogen receptor, regulate expression level of the estrogen receptor down or induce degradation of the estrogen receptor and can be used for preventing or treating diseases related to overactivity of the estrogen receptor, especially estrogen receptor positive (ER+) drug-resistant diseases (such as breast cancer producing drug resistance to anti-estrogen therapy).

Process for the preparation of 1-fluoro-cyclopropane-1-carboxylic acid

A new process for the preparation of 1-fluoro-cyclopropane-1-carboxylic acid of the formula STR1 which process comprises a) reacting in a first step, a 1-fluoro-cyclopropyl phenyl ketone of the formula STR2 in which R represents hydrogen, halogen, methyl, methoxy, phenyl or phenoxy, with an peroxy compound in the presence of a diluent, and b) reacting, in a second step, the resulting 1-fluoro-cyclopropane-1-carboxylate of the formula STR3 in which R has the abovementioned meaning, with a base in the presence of a diluent, and then acidifying the mixture. New 1-fluoro-cyclopropane-1-carboxylates of the above-mentioned formula.

Fungicides which are N-pyridyl-cyclopropane carboxamides or derivatives thereof

Compounds of having the general formula (I): STR1 and stereoisomers thereof, wherein R1 is hydrogen, halogen, C1-4 alkoxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 haloalkoxy, COR or cyano; R2, R3 and R4 are independently hydrogen, halogen or methyl, provided that R2, R3 and R4 are not all hydrogen and provided that when one of them is methyl then at least one of the other two is not hydrogen; STR2 wherein R5 is hydrogen, C1-4 alkyl (optionally substituted by hydrogen or cyano), optionally substituted benzyl, C2-4 alkenyl, C2-4 alkynyl, cyano, COR, C1-4 thioalkoxy, C1-4 thiohaloalkoxy or SNR7 R8 ; R7 and R8 are independently C1-4 alkyl or CO2 R; Y is oxygen or sulphur; R6 is C1-4 alkoxy, C1-4 thioalkoxy or --NR9 R10 ; and R9 and R10 are independently hydrogen, C1-4 alkyl, aryl or aralkyl or R9 and R10 join to form an optionally substituted heterocyclic ring and R is C1-4 alkyl or C3-7 cycloalkyl . These compounds are fungicidally active.