138068-37-8

Basic information

• Product Name: Lepirudin
• Synonyms: 1-L-Leucine-2-L-threonine-63-desulfo-hirudin (Hirudo medicinalis isoform HV1);HBW 023;N-Ile1-Thr2-63-desulfato-r-hirudin;Refludan;(Leu1,Thr2)-Hirudin (desulfated);H-Leu-Thr-Tyr-Thr-Asp-Cys-Thr-Glu-Ser-Gly-Gln-Asn-Leu-Cys-Leu-Cys-Glu-Gly-Ser-Asn-Val-Cys-Gly-Gln-Gly-Asn-Lys-Cys-Ile-Leu-Gly-Ser-Asp-Gly-Glu-Lys-Asn-Gln-Cys-Val-Thr-Gly-Glu-Gly-Thr-Pro-Lys-Pro-Gln-Ser-His-Asn-Asp-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH;H-Leu-Thr-Tyr-Thr-Asp-Cys-Thr-Glu-Ser-Gly-Gln-Asn-Leu-Cys-Leu-Cys-Glu-Gly-Ser-Asn-Val-Cys-Gly-Gln-Gly-Asn-Lys-Cys-Ile-Leu-Gly-Ser-Asp-Gly-Glu-Lys-Asn-Gln-Cys-Val-Thr-Gly-Glu-Gly-Thr-Pro-Lys-Pro-Gln-Ser-His-Asn-Asp-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-L
• CAS NO: 138068-37-8
• Molecular Formula: C287H440N80O111S6
• Molecular Weight: 6979.48
• Mol File: 138068-37-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Lepirudin(CAS DataBase Reference)
• NIST Chemistry Reference: Lepirudin(138068-37-8)
• EPA Substance Registry System: Lepirudin(138068-37-8)

Safety Data

• Hazardous Substances Data: 138068-37-8(Hazardous Substances Data)

Usage

Uses

Used in Medical Applications:
Lepirudin is used as an anticoagulant for the prevention and treatment of blood clots in patients with heparin-induced thrombocytopenia (HIT). It is particularly effective in situations where heparin cannot be used due to the patient's immune response. By inhibiting thrombin, Lepirudin helps to prevent clot formation and reduce the risk of complications associated with HIT.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Lepirudin is utilized as a therapeutic agent for managing heparin-induced thrombocytopenia and its associated complications. Its direct inhibition of thrombin makes it a valuable option for patients who cannot tolerate heparin, offering an alternative approach to anticoagulation therapy.

InChI:InChI=1/C287H446N80O111S6/c1-24-132(17)225(359-272(462)187(122-483)350-242(432)147(41-30-33-81-289)322-258(448)170(95-197(297)384)317-206(393)108-303-233(423)148(54-67-192(292)379)313-202(389)107-310-240(430)183(118-479)355-278(468)223(130(13)14)357-265(455)174(99-201(301)388)342-266(456)180(115-369)319-208(395)110-304-235(425)150(60-73-212(400)401)323-269(459)184(119-480)352-254(444)165(90-129(11)12)335-270(460)185(120-481)353-253(443)164(89-128(9)10)334-260(450)172(97-199(299)386)340-244(434)151(55-68-193(293)380)315-204(391)106-309-239(429)179(114-368)348-249(439)158(65-78-217(410)411)330-281(471)229(136(21)374)363-273(463)188(123-484)354-263(453)178(103-222(420)421)347-283(473)230(137(22)375)362-264(454)168(93-141-48-52-144(378)53-49-141)346-282(472)228(135(20)373)361-232(422)145(291)86-125(3)4)280(470)345-162(87-126(5)6)236(426)306-111-209(396)320-181(116-370)267(457)344-176(101-220(416)417)238(428)307-105-203(390)316-152(61-74-213(402)403)243(433)321-146(40-29-32-80-288)241(431)339-171(96-198(298)385)25