138528-06-0

Basic information

• Product Name: (2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-hydroxymethylpyrrolidine
• Synonyms: (2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-hydroxymethylpyrrolidine
• CAS NO: 138528-06-0
• Molecular Weight: 321.417
• Mol File: 138528-06-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-hydroxymethylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-hydroxymethylpyrrolidine(138528-06-0)
• EPA Substance Registry System: (2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-hydroxymethylpyrrolidine(138528-06-0)

Safety Data

• Hazardous Substances Data: 138528-06-0(Hazardous Substances Data)

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 14618-80-5 (R)-benzyl glycidol 
• 126550-69-4 2-((R)-1-Benzyloxymethyl-pent-4-enyl)-isoindole-1,3-dione 
• 126550-72-9 (2S,5S)-2-benzyloxymethyl-5-benzoyloxymethylpyrrolidine 
• 126550-71-8 (S)-1-benzyloxy-2-benzoylaminohex-5-ene 
• 155418-40-9 (2S)-1-(benzyloxy)hex-5-en-2-ol 
• 126550-70-7 (R)-1-Benzyloxymethyl-pent-4-enylamine 
• 152612-41-4 (2S,5S)-2-Benzyloxymethyl-5-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 56-86-0 L-glutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 159516-84-4 (2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-cyanopyrrolidine 
• 195964-54-6 1-tert-butyl 2-methyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate 
• 188200-05-7 1-(tertbutyloxycarbonyl)-5-(hydroxy)pyrrolidine-2-carboxylic acid methyl ester 

Downstream Products

• 81702-31-0 (2S,5S)-pyrrolidine-2,5-dicarboxylic acid 
• 871810-92-3 (2S)-benzyloxymethyl-1-tert-butoxycarbonyl-(5S)-methansulfonyloxymethylpyrrolidine 
• 877665-34-4 C₃₂H₃₈F₂N₄O₆ 
• 877665-02-6 C₃₁H₃₈F₂N₄O₆ 
• 877664-06-7 C₃₁H₃₈F₂N₄O₅ 
• 1416961-40-4 C₃₀H₃₅F₂N₃O₇S 
• 1416961-39-1 C₃₀H₃₅F₂N₃O₅S 
• 1416961-38-0 C₂₉H₃₂F₃N₃O₅ 
• 1416961-35-7 C₃₁H₃₈FN₃O₆ 
• 1416961-34-6 C₃₁H₃₇F₂N₃O₆ 
• 1416961-33-5 C₃₀H₃₆FN₃O₆ 
• 1416961-29-9 methyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-methanesulfonylmethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate 
• 877665-54-8 ethyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-(3-methoxyazetidinylmethyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate 
• 877665-41-3 ethyl trans-4-[1-[[7-fluoro-2-[[5-fluoro-2-methylphenyl]amino]-6-benzoxazolyl]acetyl]-(5S)-(4-morpholinyl)methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate 

Relevant articles and documents

Synthetic studies on quinocarcin and its related compounds. 3. Synthesis of 5-substituted- and 3,5-disubstituted-2-formyl-pyrrolidine derivatives, the key D-ring fragments of enantiomeric pairs of quinocarcin and 1

The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials.

CONCISE SYNTHESIS OF C2-SYMMETRIC TRANS-2,5-DIOXYMETHYLPYRROLIDINE DERIVATIVES BY NOVEL CYCLIZATION

Treatment of (S)-1-benzyloxy-2-benzoylaminohex-5-ene with iodine in aqueous acetonitrile furnished (2S,5S)-5-benzoyloxymethyl-2-bemzyloxymethylpyrrolidine stereoselectively in a single step.The product was converted into C2-symmetric (2S,5S)-2,5-dioxymethylpyrrolidines potentially utilizable as chiral auxiliaries and (2S,5S)-(-)-pyrrolidine-2,5-dicarboxylic acid isolated from marine alga Schizymenia dubyi.