138555-70-1

Basic information

• Product Name: 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE
• Synonyms: 3,5-BIS(TRIFLUOROMETHYL)PHENYLAZOMALONONITRILE;2-(2-[3,5-DI(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE;2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE;(3,5-Bis(trifluoroMethyl)phenyl)carbonohydrazonoyl dicyanide
• CAS NO: 138555-70-1
• Molecular Formula: C₁₁H₄F₆N₄
• Molecular Weight: 306.17
• Mol File: 138555-70-1.mol

Chemical Properties

• Melting Point: 138-140
• Boiling Point: 269.1°C at 760 mmHg
• Flash Point: 116.5°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 0.0074mmHg at 25°C
• Refractive Index: 1.485
• CAS DataBase Reference: 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE(138555-70-1)
• EPA Substance Registry System: 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE(138555-70-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 138555-70-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE is used as a key intermediate in organic synthesis for the preparation of a wide range of organic compounds. Its high reactivity allows for the formation of various chemical bonds and the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE is used as a building block for the development of new drugs. Its unique structure and reactivity enable the creation of novel molecular entities with potential therapeutic applications.
Used in Agrochemical Industry:
2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE is also utilized in the agrochemical industry as a precursor for the synthesis of new pesticides and other agrochemicals. Its reactivity and structural features contribute to the development of innovative and effective products for agricultural applications.
Used in Material Science:
In the field of material science, 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE is employed as a component in the development of new materials with unique properties. Its incorporation into various material systems can lead to the creation of advanced materials with improved performance characteristics.

InChI:InChI=1/C11H4F6N4/c12-10(13,14)6-1-7(11(15,16)17)3-8(2-6)20-21-9(4-18)5-19/h1-3,20H

Upstream product

• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 109-77-3 malononitrile 

Downstream Products

• 28233-12-7 N-Nonanoyl-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 
• 28455-31-4 N-3-Methylcrotonoyl-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 
• 28233-10-5 N-Carbo-hexoxy-(dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon) 
• 28455-30-3 N-Benzoyl-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 
• 28233-11-6 N-Carbo-2,2-dimethylhexyloxy-(dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon) 
• 28240-53-1 N-Butyryl-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 
• 28233-08-1 N-Carbo-phenoxy-(dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon) 
• 28232-99-7 2-(α,α,α,α',α',α'-Hexafluoro-3,5-xylyl)-4,4-dimethyl-3-thiosemicarbazone-mesoxalonitril 
• 28232-91-9 N-(4-Chlorobutyryl)-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 
• 28233-15-0 N-Cyclohexyloxycarbonyl-(dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon) 
• 28232-92-0 N-Carbo-isobutoxy-(dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon) 
• 28225-20-9 N-(3-Chloropropionyl)-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 
• 28233-07-0 N-Carbomethoxy-(dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon) 
• 28240-57-5 N-Acetyl-dicyanocarbonyl-3,5-bistrifluoromethylphenylhydrazon 

Relevant articles and documents

Effect of new carbonyl cyanide aromatic hydrazones on biofilm inhibition against methicillin resistant: Staphylococcus aureus

Carbonyl cyanide m-chlorophenylhydrazone (CCCP), as a protonophore, in combination with antibiotics exhibited potentiating antibacterial activity. To improve CCCP's potency and toxicity, a series of aromatic hydrazones were synthesized and their antimicrobial activity was evaluated; amongst them, compounds 2e and 2j with a strong para-electron-withdrawing substituent (-NO2 and -CF3) at the phenyl ring had the lowest MICs against both S. aureus and methicillin resistant Staphylococcus aureus (1.56 and 1.56 μM, respectively). Some compounds in combination with antibiotics exhibited potentiate Gram-positive antibacterial activity; compound 2e was found to display unaided or synergistic efficacy against MRSA. In particular, when compound 2e is combined with ofloxacin, it has a good synergistic effect against MRSA. Moreover, electron microscopy revealed that compound 2e inhibits biofilm formation and effectively eradicates preformed biofilm. MTT assay showed that compound 2e displays as low toxicity as CCCP. Overall, our data showed that the aromatic hydrazone is a promising scaffold for anti-staphylococcal drug development.

Method for the determination of an ion with increased sensitivity, use of substances which are suitable for this and a corresponding agent

The invention relates to a method for determining an ion in an aqueous sample. The method involves contacting the sample with a water immiscible material including an ionophore, a pH indicator and a compound which stabilizes sensitivity of the assay. The