13860-66-7

Basic information

• Product Name: N3PT
• Synonyms: N3PT;N3-pyridyl thiaMine;3-[(2-Amino-6-methyl-3-pyridyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride
• CAS NO: 13860-66-7
• Molecular Formula: C₁₃H₁₈N₃OS*ClH*Cl
• Molecular Weight: 336.28046
• Mol File: 13860-66-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 225℃
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: N3PT(CAS DataBase Reference)
• NIST Chemistry Reference: N3PT(13860-66-7)
• EPA Substance Registry System: N3PT(13860-66-7)

Safety Data

• Hazardous Substances Data: 13860-66-7(Hazardous Substances Data)

Usage

General Description

N3PT, also known as tris(2-aminoethyl)amine, is a chemical compound that belongs to the class of amines. It is a colorless liquid at room temperature and has a distinctive amine odor. N3PT is commonly used as a chelating agent in biochemistry, medical research, and analytical chemistry due to its ability to form stable complexes with metal ions. It is also used in the manufacturing of pharmaceuticals, dyes, and polymers. Additionally, N3PT has applications in water treatment and as a corrosion inhibitor. It is important to handle N3PT with care as it can be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

Upstream product

• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 13051-49-5 5-Acetoxy-3-chloropentan-2-one 
• 70959-85-2 ethyl 2-amino-6-methylnicotinate 
• 856956-20-2 6-methyl-2-amino-3-hydroxymethylpyridine 

Downstream Products

• 42784-74-7 2-(2,7-dimethyl-10-phenyl-5,10-dihydro-pyrido[2',3':4,5]pyrimido[2,1-c][1,4]thiazin-8-yl)-ethanol 

Relevant articles and documents

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3′-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes α-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described.