139262-23-0 Usage
Uses
Used in Pharmaceutical Industry:
Nalpha-Fmoc-L-lysine hydrochloride is used as an active pharmaceutical intermediate for the synthesis of various peptide-based drugs and therapeutic agents. The Fmoc group serves as a temporary protecting group during the stepwise assembly of peptides, allowing for the controlled addition of amino acids to the growing peptide chain.
Used in Biochemical Research:
In the field of biochemistry, Nalpha-Fmoc-L-lysine hydrochloride is used as a building block for the synthesis of modified peptides and proteins with specific functions. These modified peptides can be employed in various research applications, such as studying protein-protein interactions, enzyme substrate specificity, and the development of novel bioactive molecules.
Used in Protease Cleavage Detection:
Nalpha-Fmoc-L-lysine hydrochloride is also used in the synthesis of nε-(7-diethylaminocoumarin-3-carboxyl)and nε-(7-methoxycoumarin-3-carboxyl)-L-fmoc lysine, which serve as tools for protease cleavage detection by fluorescence. These synthetic peptides contain a coumarin-based fluorophore that emits fluorescence upon cleavage by proteases, allowing for the monitoring of protease activity and the identification of specific protease substrates.
Overall, Nalpha-Fmoc-L-lysine hydrochloride is a versatile compound with applications in the pharmaceutical industry, biochemistry research, and the development of novel detection methods for protease activity. Its unique chemical properties and the presence of the Fmoc protecting group make it an essential component in the synthesis of various peptide-based therapeutics and research tools.
Check Digit Verification of cas no
The CAS Registry Mumber 139262-23-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,2,6 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139262-23:
(8*1)+(7*3)+(6*9)+(5*2)+(4*6)+(3*2)+(2*2)+(1*3)=130
130 % 10 = 0
So 139262-23-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H24N2O4.ClH/c22-12-6-5-11-19(20(24)25)23-21(26)27-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18;/h1-4,7-10,18-19H,5-6,11-13,22H2,(H,23,26)(H,24,25);1H/t19-;/m0./s1
139262-23-0Relevant articles and documents
Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition
Belle, Roman,Al Temimi, Abbas H. K.,Kumar, Kiran,Pieters, Bas J. G. E.,Tumber, Anthony,Dunford, James E.,Johansson, Catrine,Oppermann, Udo,Brown, Tom,Schofield, Christopher J.,Hopkinson, Richard J.,Paton, Robert S.,Kawamura, Akane,Mecinovi?, Jasmin
supporting information, p. 13264 - 13267 (2017/12/26)
Histone lysine methylation is regulated by N?-methyltransferases, demethylases, and N?-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigen
