1395027-50-5

Basic information

• Product Name: 4-(2,6-dichlorophenyl)-8-methylsulfanyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one
• Synonyms: 4-(2,6-dichlorophenyl)-8-methylsulfanyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one
• CAS NO: 1395027-50-5
• Molecular Weight: 378.241
• Mol File: 1395027-50-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2,6-dichlorophenyl)-8-methylsulfanyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,6-dichlorophenyl)-8-methylsulfanyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one(1395027-50-5)
• EPA Substance Registry System: 4-(2,6-dichlorophenyl)-8-methylsulfanyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one(1395027-50-5)

Safety Data

• Hazardous Substances Data: 1395027-50-5(Hazardous Substances Data)

Upstream product

• 1395027-49-2 3-(2,6-dichlorophenyl)-2-(2,2-dimethoxyethylamino)-7-(methylthio)pyrimido[4,5-d]pyrimidin-4(3H)-one 
• 1395027-48-1 2-chloro-3-(2,6-dichlorophenyl)-7-(methylthio)pyrimido[4,5-d]pyrimidin-4(3H)-one 
• 1092795-08-8 3-(2,6-dichlorophenyl)-7-(methylthio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione 
• 39920-37-1 2,6-dichlorophenylisocyanate 
• 776-53-4 ethyl 4-amino-2-methylmercaptopyrimidine-5-carboxylate 

Downstream Products

• 1395027-51-6 4-(2,6-dichlorophenyl)-8-methanesulfinyl-4H-3,4,7,9,9b-pentaazacyclopenta[a]naphthalene 5-one 
• 1395027-86-7 6-(2,6-dichlorophenyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395029-11-4 6-(2,6-dichlorophenyl)-2-[(1,1,2-trimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino]imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395028-72-4 6-(2,6-dichlorophenyl)-2-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}amino)imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395030-27-9 2-[(2'-acetyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-6-(2,6-dichlorophenyl)imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395030-26-8 6-(2,6-dichlorophenyl)-2-{[2'-(methylsulfonyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl]amino}imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395028-43-9 6-(2,6-dichlorophenyl)-2-(2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-ylamino)imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395028-60-0 6-(2,6-dichlorophenyl)-2-({4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}amino)imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one 
• 1395028-44-0 tert-butyl 7'-{[6-(2,6-dichlorophenyl)-5-oxo-5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-2-yl]amino}-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2'(3'H)-carboxylate 

Relevant articles and documents

Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase

Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure-activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM Ki values. The potent inhibitors demonstrated sub-μM activities in both functional and mechanism-based cellular assays and also possessed desirable pharmacokinetic profiles. The lead molecule, 31, showed oral efficacy in potentiating the antiproliferative activity of irinotecan, a cytotoxic agent, in a NCI-H1299 mouse xenograft model.