140-38-5

Basic information

• Product Name: 4-Chlorophenylurea
• Synonyms: 1-(p-chlorophenyl)-ure;1-(p-Chlorophenyl)urea;p-CPU;Urea, (4-chlorophenyl)-;Urea, (p-chlorophenyl)-;Urea, 1-(p-chlorophenyl)-;P-CHLOROPHENYL UREA;N-(4-CHLOROPHENYL)UREA
• CAS NO: 140-38-5
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.6
• EINECS: 205-412-6
• Mol File: 140-38-5.mol
• Article Data: 48

Chemical Properties

• Melting Point: 204-205°C
• Boiling Point: 271.7°Cat760mmHg
• Flash Point: 118.1°C
• Appearance: white granular / prill
• Density: 1.402g/cm³
• Vapor Pressure: 0.00634mmHg at 25°C
• Refractive Index: 1.649
• PKA: 14.13±0.70(Predicted)
• BRN: 908492
• CAS DataBase Reference: 4-Chlorophenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorophenylurea(140-38-5)
• EPA Substance Registry System: 4-Chlorophenylurea(140-38-5)

Safety Data

• Safety Statements: 22-24/25
• RTECS: YS6127000
• HazardClass: IRRITANT
• Hazardous Substances Data: 140-38-5(Hazardous Substances Data)

Usage

General Description

4-Chlorophenylurea, also known as 4-CPU, is a chemical compound that is commonly used in the field of agriculture as a plant growth regulator. It is known for its ability to regulate the growth and development of plants, including inhibiting shoot growth and promoting lateral bud development. 4-Chlorophenylurea has also been used in studies to investigate its effects on photosynthetic processes and its potential role in controlling plant diseases and pests. Additionally, it has been explored for its potential applications in improving the shelf life and postharvest quality of fruits and vegetables. Overall, 4-Chlorophenylurea is a versatile chemical with important agricultural implications for enhancing plant growth and development.

InChI:InChI=1/C7H7ClN2O/c8-5-1-3-6(4-2-5)10-7(9)11/h1-4H,(H3,9,10,11)

Upstream product

• 684-93-5 1-methyl-1-nitrosourea 
• 106-47-8 4-chloro-aniline 
• 590-28-3 potassium cyanate 
• 57-13-6 urea 
• 103-72-0 phenyl isothiocyanate 
• 45964-97-4 1-(4-chlorophenyl)guanidine 
• 2386-64-3 ethylmagnesium chloride 
• 100-66-3 methoxybenzene 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 
• 35367-38-5 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea 
• 124-41-4 sodium methylate 
• 917-61-3 sodium isocyanate 
• 64-10-8 phenyl carbamate 
• 64-19-7 acetic acid 

Downstream Products

• 859732-53-9 1-(4-chloro-6-methyl-2-pyrimidinyl)-3-(p-chlorophenyl)urea 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 
• 32772-86-4 N-acetyl-N'-(4-chloro-phenyl)-urea 
• 148719-19-1 N-<(4-methylphenyl)sulfinyl>-N'-(4-chlorophenyl)urea 
• 58247-24-8 1-(4-chlorophenyl)-3-amidinourea 
• 65440-23-5 4-(4-chloro-phenyl)-allophanic acid ethyl ester 
• 872265-87-7 N-chloro-N'-(4-chloro-phenyl)-urea 
• 872265-82-2 N,N-dichloro-N'-(2,4-dichloro-phenyl)-urea 
• 872265-83-3 N-chloro-N'-(2,4,6-trichloro-phenyl)-urea 
• 100948-89-8 (4-chloro-2,6-dinitro-phenyl)-urea 
• 94378-57-1 N-<4-Chlor-phenyl>-N'-<2-(cyclohexen-(1)-yl)-cyclohexen-(1)-yl>-harnstoff 
• 150-68-5 monuron 
• 35367-38-5 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea 
• 122987-01-3 N-(4-chlorophenyl)-2,6-difluorobenzamide 

Relevant articles and documents

Design and synthesis of novel N-(4-(Pyridin-2-yloxy)benzylidene)-4-[4-(substituted)phenyl]semicarbazides as potential anticonvulsant agents

A new series of N-(4-(pyridin-2-yloxy)benzylidene)-4-[4-(substituted)phenyl]semicarbazides (PSSD1-8) were designed and synthesized keeping in view the structural requirement of pharmacophore and evaluated for their possible anticonvulsant activity. All the derivatives were synthesized by the given scheme and reaction process was monitored by thin layer chromatography. The structure of synthesized derivatives was confirmed by FT-IR, 1H NMR, mass spectroscopy and elemental analysis. The anticonvulsant activity was established after intraperitoneal administration in MES and scMET seizure models. The most active compound of the series was 1-(4-(pyridin-2-yloxy)-benzylidene)-4-p-tolylsemicarbazide (PSSD5). A molecular docking study was carried out in order to assess the interaction and binding modes with target receptor/enzyme. Titled compounds were found to strongly bind to human gamma-aminobutyric acid receptor (GABAAR-β3). A computational study was also carried to predict the pharmacokinetic properties of the synthesized compounds.

Nano cerium oxide as a recyclable catalyst for the synthesis of N-monosubstituted ureas with the aid of acetaldoxime as an effective water surrogate

A new method for the synthesis of N-monosubstituted ureas has been developed by the reaction of cyanamides with acetaldoxime in the presence of nano cerium oxide as an efficient and recyclable catalyst.

Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

Dual palladium-photoredox catalyzed chemoselective C-H arylation of phenylureas

A highly chemoselective C-H arylation of phenylureas has been accomplished using dual palladium-photoredox catalysis at room temperature without any additives, base or external oxidants. Regioselective C-H arylation ofN,N'-diaryl substituted unsymmetrical phenylureas has also been accomplished by a careful choice of aryl groups.