14064-13-2

Basic information

• Product Name: 1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE
• Synonyms: (1-METHYLCYCLOHEXANYL)METHANOL;1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE;Cyclohexanemethanol, 1-methyl-;1-Methyl-1-cyclohexaneMethanol;(1-Methylcyclohexyl)Methanol;1-methylcyclohexanemethanol
• CAS NO: 14064-13-2
• Molecular Formula: C₈H₁₆O
• Molecular Weight: 128.21
• Product Categories: pharmacetical;Miscellaneous Reagents
• Mol File: 14064-13-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 183.8°Cat760mmHg
• Flash Point: 74.7°C
• Appearance: /
• Density: 0.893g/cm³
• Vapor Pressure: 0.217mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE(14064-13-2)
• EPA Substance Registry System: 1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE(14064-13-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 14064-13-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

1-Hydroxymethyl-1-methylcyclohexane (cas# 14064-13-2) is a compound useful in organic synthesis.

InChI:InChI=1/C8H16O/c1-8(7-9)5-3-2-4-6-8/h9H,2-7H2,1H3

Upstream product

• 825-04-7 methyl 1-methylcyclohexanecarboxylate 
• 104654-67-3 1-(Toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid methyl ester 
• 75-24-1 trimethylaluminum 
• 15753-47-6 1-(hydroxymethyl)cyclohexanol 
• 6493-80-7 methyl 1-methyl-3-cyclohexenecarboxylate 
• 590-67-0 1-Methylcyclohexanol 
• 18448-47-0 methyl cyclohex-1-ene-1-carboxylate 
• 4845-04-9 1-cyclohexene-1-methanol 
• 16646-42-7 1-methyl-3-cyclohexenecarboxylic acid 
• 5454-79-5 cis-3-methylcyclohexanol 
• 7443-52-9 (+/-)-trans-2-methylcyclohexanol 
• 7731-29-5 trans-4-methylcyclohexan-1-ol 
• 502-41-0 cycloheptanol 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 102944-34-3 adipic acid bis-(1-methyl-cyclohexylmethyl ester) 
• 34541-92-9 Bis-(1-methylcyclohexylmethyl)aether 
• 85003-01-6 2-(1-Methyl-cyclohexylmethoxy)-5-nitro-pyridine 
• 825-04-7 methyl 1-methylcyclohexanecarboxylate 
• 79615-67-1 4-(1-methylcyclohexylmethoxy)benzonitrile 
• 6140-64-3 1-methylcyclohexanecarbaldehyde 
• 1678-91-7 ethyl-cyclohexane 
• 638-04-0 1,3-dimethylcyclohexane 
• 4126-78-7 methylcycloheptane 
• 1124-98-7 1-ethylcyclohexane-1-carboxylic acid 
• 62718-34-7 1-methylcyclohexanecarbonitrile 
• 10578-32-2 decanedioic acid bis-(1-methyl-cyclohexylmethyl ester) 
• 28509-10-6 1-ethynyl-1-methylcyclohexane 
• 50993-21-0 1-methyl-N-phenylcyclohexane-1-carboxamide 

Relevant articles and documents

Preparation of isoquinazolines: Via metal-free [4 + 2] cycloaddition of ynamides with nitriles

TfOH-mediated [4 + 2] cycloaddition of ynamides with nitriles to construct 1,2-dihydroquinazolines is realized by a direct reaction in moderate to excellent yields (up to 93%) in a stereospecific manner. A rapid and efficient strategy has been employed for the syntheses of alkyl-substituted 1,2-dihydroquinazoline derivatives, and it exhibits good functional group tolerance, has a short reaction time, shows excellent diastereoselectivity, and is a simple and high-yielding reaction.

Hemilabile Benzyl Ether Enables γ-C(sp3)-H Carbonylation and Olefination of Alcohols

Pd-catalyzed C(sp3)-H activation of alcohol typically shows β-selectivity due to the required distance between the chelating atom in the attached directing group and the targeted C-H bonds. Herein we report the design of a hemilabile directing group which exploits the chelation of a readily removable benzyl ether moiety to direct γ- or δ-C-H carbonylation and olefination of alcohols. The utility of this approach is also demonstrated in the late-stage C-H functionalization of β-estradiol to rapidly prepare desired analogues that required multi-step syntheses with classical methods.

CYCLOALKYL METHOXYBENZYL PHENYL PYRAN DERIVATIVES AS SODIUM DEPENDENT GLUCOSE CO TRANSPORTER (SGLT2) INHIBITORS

The invention relates to the cycloalkyl methoxybenzyl phenyl pyran derivatives as Sodium dependent glucose co transporter (SGLT) inhibitors, particularly SGLT2 and method of treating diseases, conditions and/or disorders inhibited by SGLT2 with them, and processes for preparing them.