140658-45-3

Usage

Uses

Used in Food Preservation:
Benzoic acid, 4,4'-[1,3-propanediylbis(oxy)]bis[5-methoxy-2-nitrois used as a food preservative for its antimicrobial properties, which help to prevent spoilage and extend the shelf life of food products by inhibiting the growth of mold, yeast, and bacteria.
Used in Industrial Production:
In the industrial sector, Benzoic acid, 4,4'-[1,3-propanediylbis(oxy)]bis[5-methoxy-2-nitrois utilized in the manufacturing of dyes, perfumes, and pharmaceuticals, capitalizing on its chemical properties to enhance the quality and performance of these products.
Used in Pharmaceutical and Medical Applications:
Benzoic acid, 4,4'-[1,3-propanediylbis(oxy)]bis[5-methoxy-2-nitroalso has potential applications in medicine, where it can be employed for its antibacterial and antifungal properties, contributing to the treatment and prevention of various infections.
Used in Chemical Research:
Furthermore, Benzoic acid, 4,4'-[1,3-propanediylbis(oxy)]bis[5-methoxy-2-nitromay be used in chemical research for studying its properties and potential reactions, which could lead to the development of new compounds and applications.
It is crucial to handle Benzoic acid, 4,4'-[1,3-propanediylbis(oxy)]bis[5-methoxy-2-nitro- with care due to its irritant properties and potential health hazards, ensuring that proper safety measures are in place during its use in various industries.

Upstream product

• 140658-44-2 1,1'-[(propane-1,3-diyl)dioxy]bis[(5-methoxy-2-nitro-1,4-phenylene)carbonyl]bis[(2S,4R)-methyl-4-hydroxypyrrolidine-2-carboxylate] 
• 3018-48-2 1',3'-bis(4-carboxy-2-methoxyphenoxy)propane 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 130107-96-9 1',3'-bis<2-methoxy-(4-methoxycarbonyl)phenoxy>propane 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 

Downstream Products

• 140658-46-4 1,1'-<<(propane-1,3-diyl)dioxy>bis<(2-nitro-5-methoxy-1,4-phenylene)carbonyl>>bis 
• 260391-64-8 ((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone) 
• 232931-63-4 1,1'-[[(propane-1,3-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S)-2-hydroxymethyl-4-methylidene-2,3-dihydropyrrole] 
• 260417-96-7 1,1'-[[(propane-1,3-diyl)dioxy]-bis[(2-amino-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S,4R)-2-t-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine] 
• 260417-95-6 1,1'-[[(propane-1,3-diyl)dioxy]-bis[(2-nitro-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S,4R)-2-t-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine] 
• 260417-98-9 1,1'-[[(propane-1,3-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S)-2-t-butyldimethylsilyloxymethyl-4-oxo-pyrrolidine] 
• 260417-97-8 1,1'-[[(propane-1,3-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S,4R)-2-t-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine] 
• 260418-24-4 1,1'-[[(propane-1,3-diyl)dioxy]-bis[(2-amino-N-allyloxycarbonyl-5-methoxy-1,4-phenylene)carbonyl]]-bis[(2S)-2-t-butyldimethylsilyloxymethyl-4-methylidene-2,3-dihydropyrrole] 
• 140658-44-2 1,1'-[(propane-1,3-diyl)dioxy]bis[(5-methoxy-2-nitro-1,4-phenylene)carbonyl]bis[(2S,4R)-methyl-4-hydroxypyrrolidine-2-carboxylate] 
• 1201630-40-1 1,1‘-[[(propane-1,3-diyl)dioxy]bis[(5-methoxy-2-nitro-1,4-phenylene)carbonyl]]bis[(2S,4R)-methyl-4-hydroxypyrrolidine-2-carboxylate] 
• 1343407-77-1 (2S,2'S,E)-dimethyl 1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitrobenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2-carboxylate) 
• 1343407-78-2 (S,E)-((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)-4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrol-1-yl)methanone) 
• 1343407-79-3 ((2S,2’S,E)-1,1’-(4,4’-(propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitrobenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene)diacetate 
• 1343407-80-6 ((2S,2’S,E)-1,1’-(4,4’-(propane-1,3-diylbis(oxy))bis(2-amino-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene)diacetate 

Relevant academic research and scientific papers

PYRROLOBENZODIAZEPINE CONJUGATES

A compound of formula (I) : (I) and its conjugates.

ISOQUINOLIDINOBENZODIAZEPINES

This disclosure provides novel isoquinolidinobenzodiazepines. These compounds can also be incorporated into antibody-drug conjugates.

PYRROLOBENZODIAZEPINE CONJUGATES

A conjugate of formula (I), wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein either: (a) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (b)

PYRROLOBENZODIAZEPINE CONJUGATES

A conjugate of formula (I): L - (DL)p (I) wherein L is a Ligand unit, D is a Drug Linker unit of formula (II) wherein p is an integer of from 1 to 20.

PYRROLOBENZODIAZEPINE ANTI-HER2 ANTIBODY CONJUGATES

A conjugate of formula (I) L - (DL)p (I) wherein L is an antibody (Ab) which binds HER2, D is a Drug Linker unit of formula (A) wherein p is an integer of from 1 to 20.

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

A compound which is selected from A: and salts and solvates thereof.

PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES

Conjugates of specific PBD dimers with an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.

ANTIBODIES AND ANTIBODY-DRUG CONJUGATES

This application provides antibodies and antigen binding fragments thereof which are capable of specifically binding the 5T4 cell surface antigen, antibody-drug conjugates, and antibody-imaging agent conjugates, as well as means and methods for producing and using them.

HUMANIZED ANTI-TN-MUC1 ANTIBODIES AND THEIR CONJUGATES

Humanized anti-Tn-MUC1 antibodies and conjugates thereof. Conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker to the antibody are described.

PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES

Conjugates of specific PBD dimers with an antibody that that binds to HER2, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.