140658-45-3Relevant articles and documents
PYRROLOBENZODIAZEPINE CONJUGATES
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, (2018/04/27)
A compound of formula (I) : (I) and its conjugates.
ISOQUINOLIDINOBENZODIAZEPINES
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, (2018/04/13)
This disclosure provides novel isoquinolidinobenzodiazepines. These compounds can also be incorporated into antibody-drug conjugates.
PYRROLOBENZODIAZEPINE CONJUGATES
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, (2017/09/05)
A conjugate of formula (I), wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein either: (a) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (b)
PYRROLOBENZODIAZEPINE CONJUGATES
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, (2017/09/05)
A conjugate of formula (I): L - (DL)p (I) wherein L is a Ligand unit, D is a Drug Linker unit of formula (II) wherein p is an integer of from 1 to 20.
PYRROLOBENZODIAZEPINE ANTI-HER2 ANTIBODY CONJUGATES
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, (2017/09/07)
A conjugate of formula (I) L - (DL)p (I) wherein L is an antibody (Ab) which binds HER2, D is a Drug Linker unit of formula (A) wherein p is an integer of from 1 to 20.
PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
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, (2015/04/28)
Conjugates of specific PBD dimers with an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
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, (2015/04/28)
Conjugates of specific PBD dimers with an antibody that that binds to HER2, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
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, (2015/04/28)
Conjugates of specific PBD dimers with an antibody that binds to PSMA, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 3, 5, 7, 8, 9, or 10, optionally further comprising a VL domain having the sequence 5 according to any one of SEQ ID NOs. 2, 4, 6, 11, 12, 13, 14, 15, 16, 17, or 18.
PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
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, (2015/04/28)
Conjugates of specific PBD dimers with an antibody that that binds to CD19, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 2, 3, 4, 5 or 6, optionally further comprising a VL domain having the sequence according to any one of SEQ ID NOs. 7, 8, 9, 10, 11 or 12.
PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
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, (2015/04/28)
A compound which is selected from A: and salts and solvates thereof.