14088-99-4

Basic information

• Product Name: 1-(4-Chlorophenyl)-2-imidazolidinone
• Synonyms: 1-(4-Chlorophenyl)-2-imidazolidinone;1-(4-Chlorophenyl)imidazolidin-2-one
• CAS NO: 14088-99-4
• Molecular Formula: C₉H₉ClN₂O
• Molecular Weight: 196.63
• Mol File: 14088-99-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.324g/cm³
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• PKA: 13.79±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Chlorophenyl)-2-imidazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-2-imidazolidinone(14088-99-4)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-2-imidazolidinone(14088-99-4)

Safety Data

• Hazardous Substances Data: 14088-99-4(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-2-imidazolidinone, also known as lonidamine, is a synthetic chemical compound with a molecular formula of C9H8ClN3O. It has been studied for its potential antineoplastic and chemosensitizing effects. Lonidamine has been shown to inhibit various enzymes and processes involved in cancer cell metabolism and growth, making it a candidate for use in cancer treatment. Additionally, it has been investigated for its ability to enhance the effectiveness of chemotherapy drugs by increasing their uptake and retention in cancer cells. However, lonidamine has also been associated with certain side effects, including gastrointestinal disturbances and potential reproductive toxicity, which may limit its clinical use. Overall, this compound has shown promise as a potential therapeutic agent for cancer treatment, but further research is needed to fully understand its safety and efficacy.

InChI:InChI=1/C9H9ClN2O/c10-7-1-3-8(4-2-7)12-6-5-11-9(12)13/h1-4H,5-6H2,(H,11,13)

Upstream product

• 497-25-6 dimethylenecyclourethane 
• 106-47-8 4-chloro-aniline 
• 65536-39-2 N-(2-chloro-ethyl)-N'-(4-chloro-phenyl)-urea 
• 18523-47-2 3-azidopropanoic acid 
• 120-93-4 imidazolidone 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 519143-27-2 1-(4-chlorophenyl)-3-(5-[3-(4-methoxyphenoxy)propoxy]pentyl)-2-imidazolidinone 
• 1225208-10-5 C₁₇H₂₄ClN₃O 
• 1169705-55-8 (3-{5-[3-(4-chloro-phenyl)-2-thioxo-imidazolidin-1-yl]-pentyloxy}-phenyl)-thiourea 
• 1169705-54-7 (3-{5-[3-(4-chloro-phenyl)-2-oxo-imidazolidin-1-yl]-pentyloxy}-phenyl)-thiourea 
• 68319-89-1 1-(4-chloro-phenyl)-3-nitroso-imidazolidin-2-one 

Relevant articles and documents

Nucleophilic substitution of azide acting as a pseudo leaving group: One-step synthesis of various aza heterocycles

The reaction of 3-azidopropanoic acid with the carbodiimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile precursor to a diverse set of aza heterocycles, including mono-, bi-, and tricyclic compounds.

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors

A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships