141090-47-3

Basic information

• Product Name: 1-propyl-3-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
• Synonyms: 1-propyl-3-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
• CAS NO: 141090-47-3
• Molecular Weight: 217.311
• Mol File: 141090-47-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-propyl-3-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-propyl-3-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine(141090-47-3)
• EPA Substance Registry System: 1-propyl-3-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine(141090-47-3)

Safety Data

• Hazardous Substances Data: 141090-47-3(Hazardous Substances Data)

Upstream product

• 53385-78-7 1-propyl-1,2,3,6-tetrahydropyridine 
• 626-02-8 3-Iodophenol 

Relevant articles and documents

Optimizing the Mizoroki–Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups

Though a widely used metal-catalyzed cross-coupling process, the Mizoroki–Heck (MH) reaction can be a capricious transformation. This is particularly true for oxidation-prone alkene substrates containing ligating heteroatoms, as in the case of N-alkyl tetrahydropyridines, whose MH reactions have been underexplored due to the many side reactions that hamper the process. Since the products of tetrahydropyridine Heck reactions are direct precursors to potent pharmacophores, and therefore of commercial value, this is a significant drawback. We report here the results of our study designed to deliver an optimized, scalable MH procedure for N-alkyltetrahydropyridines and its exemplification in a gram-scale synthesis of the drug substance preclamol.