141318-80-1

Basic information

• Product Name: S-3,4-Diaminobutyric acid 2HCl
• Synonyms: S-3,4-Diaminobutyric acid 2HCl;(S)-3,4-Diaminobutyric acid dihydrochloride;(S)-3,4-diaminobutanoic acid dihydrochloride;REF DUPL: S-3,4-Diaminobutyric acid 2HCl;(3S)-3,4-diaminobutanoic acid,dihydrochloride
• CAS NO: 141318-80-1
• Molecular Formula: C4H12Cl2N2O2
• Molecular Weight: 191.05628
• Mol File: 141318-80-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: S-3,4-Diaminobutyric acid 2HCl(CAS DataBase Reference)
• NIST Chemistry Reference: S-3,4-Diaminobutyric acid 2HCl(141318-80-1)
• EPA Substance Registry System: S-3,4-Diaminobutyric acid 2HCl(141318-80-1)

Safety Data

• Hazardous Substances Data: 141318-80-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
S-3,4-Diaminobutyric acid 2HCl is used as a potential drug candidate for its involvement in neurotransmission and as a building block in the synthesis of new medications. Its role in biological processes makes it a promising compound for the development of treatments for various conditions.
Used in Organic Synthesis:
S-3,4-Diaminobutyric acid 2HCl is used as a chemical building block in the synthesis of complex organic molecules. Its unique structure with two amino groups and a carboxylic acid functional group allows for the creation of a wide range of compounds with potential applications in various fields.
Used in Biological Research:
S-3,4-Diaminobutyric acid 2HCl is used as a research tool in the study of neurotransmission and other biological processes. Its potential as a drug target makes it valuable for understanding the mechanisms of action of various diseases and conditions, which can lead to the development of new therapeutic strategies.

InChI:InChI=1/C4H10N2O2.2ClH/c5-2-3(6)1-4(7)8;;/h3H,1-2,5-6H2,(H,7,8);2*1H/t3-;;/m0../s1

Upstream product

• 141291-28-3 (4S)-4-(carbo-t-butoxymethyl)-imidazolidin-2-one 
• 141291-26-1 (4R)-4-(carbomethoxymethyl)-imidazolidin-2-one 

Relevant articles and documents

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (R)-3,4-diaminobutanoic acid by desymmetrization of dimethyl 3-(benzylamino)glutarate through enzymatic ammonolysis

Lipase B from Candida antarctica is shown to be a highly efficient catalyst for the desymmetrization of dimethyl 3-(benzylamino)glutarate (1) through aminolysis and ammonolysis reactions. Using this procedure, enantiopure monoamides are obtained in high yield. The synthetic value of these compounds is demonstrated by the preparation of an enantiopure nonnatural amino acid, i.e. (R)-3,4-diaminobutanoic acid [(+)-12].

A Practical and Stereoconservative Synthesis of (R)-3-Amino-4-(trimethyl-ammonio)butanoate [(R)-Aminocarnitine], and Its Trimethylphosphonium and Simple Ammonium Analogues Starting from D-Aspartic Acid

We have developed a new stereospecific synthesis of (R)-aminocarnitine using D-aspartic acid as the starting material. This strategy, which is simple and amenable to an industrial scale-up, gives the target compound in six steps and in fairly good overall

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (3R)- and (3S)-3,4-diamino-butyric acid from L-aspartic acid

A short and convenient synthesis for both enantiomers of GABOB amino-analogue 1a,b is reported, starting from L-aspartic acid. The protected diester 3 is the common intermediate for the synthetic pathway.