14135-68-3

Basic information

• Product Name: 1-(morpholin-4-yl)-2,2-diphenylethanone
• Synonyms: 1-Morpholin-4-yl-2,2-diphenyl-ethanone; ethanone, 1-(4-morpholinyl)-2,2-diphenyl-
• CAS NO: 14135-68-3
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.349
• Mol File: 14135-68-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 471.5°C at 760 mmHg
• Flash Point: 238.9°C
• Density: 1.151g/cm³
• Vapor Pressure: 4.65E-09mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 1-(morpholin-4-yl)-2,2-diphenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(morpholin-4-yl)-2,2-diphenylethanone(14135-68-3)
• EPA Substance Registry System: 1-(morpholin-4-yl)-2,2-diphenylethanone(14135-68-3)

Safety Data

• Hazardous Substances Data: 14135-68-3(Hazardous Substances Data)

Usage

General Description

1-(morpholin-4-yl)-2,2-diphenylethanone, also known as MORPH-DPE, is a synthetic chemical compound with a molecular formula C19H21NO2. It is a ketone derivative with a morpholine ring attached to a diphenylethanone structure. 1-(morpholin-4-yl)-2,2-diphenylethanone has shown potential as a pharmaceutical intermediate and is being studied for its potential biological activities. Its unique structure and properties make it a valuable building block for the synthesis of various organic compounds. It is important to handle this chemical with proper safety precautions and in accordance with all applicable regulations.

Upstream product

• 110-91-8 morpholine 
• 117-34-0 2,2-diphenylacetic acid 
• 1696-20-4 4-acetylmorpholine 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 591-50-4 iodobenzene 
• 4467-90-7 N-hydroxy-2,2-diphenylacetimidoyl chloride 
• 81838-55-3 1-Morpholin-4-yl-2,2-diphenyl-ethanone oxime 

Relevant articles and documents

Amide formation using in situ activation of carboxylic acids with [Et 2NSF2]BF4

The formation of amides through the in situ activation of carboxylic acids with [Et2NSF2]BF4 is presented. A wide range of carboxylic acids and amines were used to produce the corresponding amides in up to 99 % yield. The reaction of hindered amines was also possible in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under slightly modified conditions. An enantiopure carboxylic acid and amine were both shown to react without racemization. Copyright

COUPLED ACYLATION OF AMINES DEPENDENT ON 3-NITRO-4-CHLOROCOUMARIN

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Photostimulated Reactions of N,N-Disubstituted Amide Enolate Anions with Haloarenes by the SRN1 Mechanism in Liquid Ammonia

The photostimulated reactions of chloro-, bromo-, and iodobenzenes, 1-chloronaphthalene, and 9-bromophenanthrene with the enolate anion of N-methyl-N-phenylacetamide in liquid ammonia gave good yields of substituted products.In the dark, iodobenzene gave 34percent of substitution product, but chlorobenzene did not react.The enolate anion of N,N-dimethylacetamide was only partially soluble in liquid ammonia, but good yields of substitution products were obtained.The enolate anion of N-acetylpiperidine was insoluble in liquid ammonia, but the enolate anion of N-acetylmorpholine was soluble and good yields of substitution products were obtained under photostimulation.It is suggested that these reactions occur by the SRN1 mechanism of aromatic substitution.