1415743-27-9Relevant articles and documents
A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore
Pauff, Steven M.,Miller, Stephen C.
, p. 711 - 716 (2013)
Sulfonated molecules exhibit high water solubility, a property that is valuable for many biological applications but often complicates their synthesis and purification. Here we report a sulfonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroacetic acid (TFA). The use of this protecting group improved the synthesis of a sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product without requiring chromatography.