Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1417745-62-0

Post Buying Request

1417745-62-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1417745-62-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1417745-62-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,7,7,4 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1417745-62:
(9*1)+(8*4)+(7*1)+(6*7)+(5*7)+(4*4)+(3*5)+(2*6)+(1*2)=170
170 % 10 = 0
So 1417745-62-0 is a valid CAS Registry Number.

1417745-62-0Downstream Products

1417745-62-0Relevant articles and documents

New bis-thiazolium analogues as potential antimalarial agents: Design, synthesis, and biological evaluation

Caldarelli, Sergio A.,El Fangour, Siham,Wein, Sharon,Tran Van Ba, Christophe,Périgaud, Christian,Pellet, Alain,Vial, Henri J.,Peyrottes, Suzanne

, p. 496 - 509 (2013/04/23)

Bis-thiazolium salts are able to inhibit phosphatidylcholine biosynthesis in Plasmodium and to block parasite proliferation in the low nanomolar range. However, due to their physicochemical properties (i.e., permanent cationic charges, the flexibility, and lipophilic character of the alkyl chain), the oral bioavailability of these compounds is low. New series of bis-thiazolium-based drugs have been designed to overcome this drawback. They feature linker rigidification via the introduction of aromatic rings and/or a decrease in the overall lipophilicity through the introduction of heteroatoms. On the basis of the structure-activity relationships, a few of the promising compounds (9, 10, and 11) were found to exhibit potent antimalarial in vitro and in vivo activities (EC50 50 ip 0.7 mg/kg).

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1417745-62-0