1422047-37-7Relevant articles and documents
Arylation, alkenylation, and alkylation of 2-halopyridine N-oxides with Grignard reagents: A solution to the problem of C2/C6 regioselective functionalization of pyridine derivatives
Zhang, Song,Liao, Lian-Yan,Zhang, Fang,Duan, Xin-Fang
, p. 2720 - 2725 (2013/05/08)
A facile arylation, alkenylation, and alkylation of functionalized 2-halopyridine N-oxides with various Grignard reagents was developed. It represented a highly efficient and selective C-H bond functionalization of pyridine derivatives in the presence of reactive C-Cl or C-Br bonds. Using Cl or Br as a blocking group, C2/C6 site-controllable functionalization of pyridine derivatives has been achieved. Various pyridine compounds can be prepared as illustrated in the total syntheses of Onychine, dielsine, and PARP-1 inhibitor GPI 16539.